INT343182

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Context Info
Confidence 0.67
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 5.04
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ACSL4) small molecule metabolic process (ACSL4) endoplasmic reticulum (ACSL4)
peroxisome (ACSL4) ligase activity (ACSL4)
Anatomy Link Frequency
MCF-7 8
colon 4
MDA-MB-231 2
ACSL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 11 91.28 High High
cINOD 11 79.12 Quite High
COX2 11 24.40 Low Low
Disease Link Frequency Relevance Heat
Colon Cancer 99 99.22 Very High Very High Very High
Breast Cancer 407 99.04 Very High Very High Very High
Injury 231 97.36 Very High Very High Very High
Apoptosis 132 95.84 Very High Very High Very High
Liver Cancer 11 93.16 High High
Cancer 154 89.64 High High
Starvation 22 86.80 High High
INFLAMMATION 11 78.88 Quite High
Hepatocellular Cancer 55 76.56 Quite High
Wound Healing 33 74.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It can therefore be argued that ACSL4 overexpression might contribute to the development of an aggressive phenotype in breast cancer cells by regulating the production of lipooxygenase and cyclooxygenase metabolites.
Positive_regulation (overexpression) of Gene_expression (overexpression) of ACSL4 associated with breast cancer
1) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.80 Pain Relevance 0.08
The formation of 5-, 12-, and 15-LOX products was significantly increased in cells overexpressing ACSL4 than in cells treated with tetracycline (Fig. 6C).
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of ACSL4
2) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.48 Pain Relevance 0
However, overexpression of ACSL4 resulted in slight by not statistically significant increase in 5-LOX expression (data not shown).
Positive_regulation (overexpression) of Gene_expression (overexpression) of ACSL4
3) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.48 Pain Relevance 0
In this system, further functional studies were performed to confirm whether an increased ACSL4 expression may lead to increased cell proliferation and migration as described above.
Positive_regulation (increased) of Gene_expression (expression) of ACSL4
4) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.26 Pain Relevance 0
Previous investigations in colon adenocarcinoma or hepatocellular cells reported that ACSL4 overexpression or inhibition associated only with increased or decreased cell proliferation respectively [3], [4], [6], [21], [38].
Positive_regulation (overexpression) of Gene_expression (overexpression) of ACSL4 in colon associated with colon cancer
5) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.80 Pain Relevance 0.05
Increased ACSL4 expression, both at mRNA and protein levels [3], in colon adenocarcinoma cells has been associated with inhibition of apoptosis and increase in cell proliferation when compared to adjacent normal tissue.
Positive_regulation (Increased) of Gene_expression (expression) of ACSL4 in colon associated with colon cancer and apoptosis
6) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.74 Pain Relevance 0
The finding that tetracycline abolished the difference in the aggressive phenotype of MCF-7 Tet-off/ACSL4 cells strongly indicates that the increase in cell proliferation, invasion and migration were a direct result of the increased ACSL4 expression.
Positive_regulation (increased) of Gene_expression (expression) of ACSL4 in MCF-7
7) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.53 Pain Relevance 0
The tetracycline-repressible MCF-7 cell line, designated MCF-7 Tet-off, was used for stably transfection of ACSL4 cDNA under control of the tetracycline-response element using the Tet-Off Gene Expression System (Clontech).
Positive_regulation (transfection) of Gene_expression (transfection) of ACSL4 cDNA in MCF-7
8) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.07 Pain Relevance 0
Another significant finding was that intramitochondrial AA levels were significantly increased in MDA-MB-231 cells as compared to those in MCF-7 cells and that increased AA levels correlated with higher expression levels of ACSL4.
Positive_regulation (levels) of Gene_expression (expression) of ACSL4 in MCF-7
9) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.61 Pain Relevance 0
However, the phenotype was changed by both overexpression and knockdown of ACOT2 in MDA-MB-231 cells that express high levels of ACSL4.
Positive_regulation (levels) of Gene_expression (express) of ACSL4 in MDA-MB-231
10) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.09 Pain Relevance 0
AA-861 blocked the effect in COX-2 levels caused by the overexpression of ACSL4 in the MCF-7 Tet-off/ACSL4 cell line (Fig. 7C).
Positive_regulation (overexpression) of Gene_expression (overexpression) of ACSL4 in MCF-7
11) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.18 Pain Relevance 0

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