INT343183

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.45
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ACSL4) small molecule metabolic process (ACSL4) endoplasmic reticulum (ACSL4)
peroxisome (ACSL4) ligase activity (ACSL4)
Anatomy Link Frequency
MCF-7 1
ACSL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 3 75.60 Quite High
COX2 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 3 100.00 Very High Very High Very High
Apoptosis 36 96.68 Very High Very High Very High
Bladder Cancer 3 95.56 Very High Very High Very High
Targeted Disruption 12 92.44 High High
Cancer 42 89.04 High High
Colon Cancer 27 87.84 High High
Hepatocellular Cancer 15 83.04 Quite High
Breast Cancer 111 76.12 Quite High
Aggression 18 42.08 Quite Low
Reprotox - General 1 3 33.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MCF-7 Tet-off-induced repression of ACSL4 cells, designated MCF-7 Tet-off/ACSL4, were further maintained in complete DMEM.


Negative_regulation (repression) of ACSL4 in MCF-7 associated with repression
1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.10 Pain Relevance 0
Moreover these results are further supported in the stable cells line where the inhibition of ACSL4 protein by tetracycline paralleled the inhibition of cell growth.
Negative_regulation (inhibition) of ACSL4 protein
2) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.43 Pain Relevance 0
It is therefore unlikely that the inhibition of ACSL4-stimulated COX-2 expression by AA861 reported here may be due to an activation of apoptosis or inhibition of cell growth or survival since the inhibition of COX-2 expression is evident at least 48 h earlier than the inhibition in cell proliferation described for different cancer cell lines.
Negative_regulation (inhibition) of ACSL4 associated with cancer and apoptosis
3) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.91 Pain Relevance 0.04

General Comments

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