INT343185

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Context Info
Confidence 0.48
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 4.56
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ACSL4) small molecule metabolic process (ACSL4) endoplasmic reticulum (ACSL4)
peroxisome (ACSL4) ligase activity (ACSL4)
Anatomy Link Frequency
colon 3
MCF-7 2
MDA-MB-231 1
ACSL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 10 88.72 High High
COX-2 inhibitor 10 76.48 Quite High
COX2 10 16.36 Low Low
Disease Link Frequency Relevance Heat
Breast Cancer 370 99.84 Very High Very High Very High
Hepatocellular Cancer 50 98.84 Very High Very High Very High
Apoptosis 120 98.00 Very High Very High Very High
Colon Cancer 90 97.20 Very High Very High Very High
Bladder Cancer 10 95.00 High High
Cancer 140 89.48 High High
Injury 210 88.76 High High
INFLAMMATION 10 88.32 High High
Starvation 20 86.36 High High
Aggression 60 66.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Functional Interaction between Acyl-CoA Synthetase 4, Lipooxygenases and Cyclooxygenase-2 in the Aggressive Phenotype of Breast Cancer Cells

The acyl-CoA synthetase 4 (ACSL4) is increased in breast cancer, colon and hepatocellular carcinoma.

Positive_regulation (increased) of acyl-CoA synthetase 4 in colon associated with hepatocellular cancer and breast cancer
1) Confidence 0.48 Published 2010 Journal PLoS ONE Section Title Doc Link PMC2978721 Disease Relevance 0.52 Pain Relevance 0
It is therefore unlikely that the inhibition of ACSL4-stimulated COX-2 expression by AA861 reported here may be due to an activation of apoptosis or inhibition of cell growth or survival since the inhibition of COX-2 expression is evident at least 48 h earlier than the inhibition in cell proliferation described for different cancer cell lines.
Positive_regulation (stimulated) of ACSL4 associated with cancer and apoptosis
2) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.91 Pain Relevance 0.04
In this work, we state that COX-2 expression in the more aggressive cells is controlled by ACSL4 through the generation of lipooxygenase metabolites since inhibition of lipooxygenase activity blunted ACSL4-dependent increase in COX-2 expression.
Positive_regulation (increase) of ACSL4-dependent
3) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.20 Pain Relevance 0
Another significant finding was that intramitochondrial AA levels were significantly increased in MDA-MB-231 cells as compared to those in MCF-7 cells and that increased AA levels correlated with higher expression levels of ACSL4.
Positive_regulation (levels) of ACSL4 in MCF-7
4) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.61 Pain Relevance 0
Functional Interaction between Acyl-CoA Synthetase 4, Lipooxygenases and Cyclooxygenase-2 in the Aggressive Phenotype of Breast Cancer Cells

The acyl-CoA synthetase 4 (ACSL4) is increased in breast cancer, colon and hepatocellular carcinoma.

Positive_regulation (increased) of ACSL4 in colon associated with hepatocellular cancer and breast cancer
5) Confidence 0.48 Published 2010 Journal PLoS ONE Section Title Doc Link PMC2978721 Disease Relevance 0.52 Pain Relevance 0
Notably, the high abundance of COX-2 correlates with the higher expression levels of ACSL4.
Positive_regulation (levels) of ACSL4
6) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.06 Pain Relevance 0
As expected, the MCF-7 Tet-off/ACSL4 cell line showed a significant increase in ACSL4 mRNA and protein, as compared with MCF-7 Tet-off control cells, and ACSL4 expression was completely repressed by the treatment of the cells with tetracycline, indicating that the system is fully functional in this cell line (Fig. 6A).
Positive_regulation (increase) of ACSL4 in MCF-7
7) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.12 Pain Relevance 0
However, the phenotype was changed by both overexpression and knockdown of ACOT2 in MDA-MB-231 cells that express high levels of ACSL4.
Positive_regulation (levels) of ACSL4 in MDA-MB-231
8) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.09 Pain Relevance 0
Thus, an apoptotic effect of AA861, other than its selective inhibition of lipoxygenase activity and causing a non-specific reduction in cell viability or survival rate, could be the cause of the attenuation of ACSL4 stimulation of COX-2.
Positive_regulation (stimulation) of ACSL4 associated with apoptosis
9) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.63 Pain Relevance 0
Previous reports have demonstrated that the simultaneous activation of the ACSL4 and COX-2 pathways results in a synergistic anti-apoptotic effect in colon cancer [21].
Positive_regulation (activation) of ACSL4 in colon associated with colon cancer and apoptosis
10) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.90 Pain Relevance 0.09

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