INT343200

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Context Info
Confidence 0.36
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.32
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ACSL4) small molecule metabolic process (ACSL4) endoplasmic reticulum (ACSL4)
peroxisome (ACSL4) ligase activity (ACSL4)
ACSL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 4 99.60 Very High Very High Very High
cINOD 4 93.04 High High
COX-2 inhibitor 4 53.88 Quite High
Disease Link Frequency Relevance Heat
Colon Cancer 36 97.92 Very High Very High Very High
Cancer 56 97.52 Very High Very High Very High
Apoptosis 48 96.84 Very High Very High Very High
Breast Cancer 148 96.76 Very High Very High Very High
INFLAMMATION 4 92.80 High High
Metastasis 8 75.60 Quite High
Noninfiltrating Intraductal Carcinoma 4 64.44 Quite High
Carcinoma 4 63.40 Quite High
Aggression 24 57.36 Quite High
Advanced Or Metastatic Breast Cancer 4 54.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This may indicate that the regulation of proliferation, migration and invasion could be due to the functional interaction of ACSL4, LOX and COX2.
ACSL4 Binding (interaction) of associated with cox2
1) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.66 Pain Relevance 0.08
We here provide evidence for such mechanism, in which ACSL4, LOX and COX-2 metabolites interact functionally.
ACSL4 Binding (interact) of
2) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 1.02 Pain Relevance 0.06
In this study, we showed that ACSL4 acts in combination with ACOT2, LOX and COX-2 to generate an aggressive phenotype in breast cancer cells.
ACSL4 Binding (acts) of associated with breast cancer
3) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.81 Pain Relevance 0.09
In this mechanism, ACSL4, LOX and COX-2 interact functionally and represent an integrated system that regulates the proliferation and metastatic potential of cancer cells.
ACSL4 Binding (interact) of associated with cancer
4) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.84 Pain Relevance 0

General Comments

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