INT343539

Context Info Confidence 0.15 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.25 Pain Relevance 0

intracellular (GLI2, PTHLH) cytoplasm (GLI2, PTHLH) nucleus (GLI2, PTHLH) cell differentiation (GLI2) Golgi apparatus (PTHLH) cilium (GLI2)

Anatomy Link Frequency MDA-MB-231 1 GLI2 (Homo sapiens) PTHLH (Homo sapiens)

Pain Link Frequency Relevance Heat Mechanotransduction 8 5.00 metalloproteinase 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Metastasis 23 75.92 Carcinoma 1 60.96 Skin Cancer 1 58.84 Adenocarcinoma 1 56.44 Advanced Or Metastatic Breast Cancer 1 50.00 Cancer 46 48.20 Pressure And Volume Under Development 3 32.08 Breast Cancer 6 5.00 Bone Cancer 6 5.00 Hypercalcemia 5 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Expression of Gli2, a transcription factor known to regulate PTHrP [4], also showed a 5-fold increase on hard substrates in both MDA-MB-231 and RWGT2 (Figure 3) but not in MCF-7 cells (data not shown).

Gli2 Regulation (regulate) of PTHrP in MDA-MB-231

1) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.25 Pain Relevance 0

General Comments

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