INT343542

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (ROCK1, PTHLH) cytoplasm (ROCK1, PTHLH) intracellular (PTHLH)
cell-cell signaling (PTHLH) cytosol (ROCK1) signal transduction (ROCK1)
Anatomy Link Frequency
MDA-MB-231 2
ROCK1 (Homo sapiens)
PTHLH (Homo sapiens)
Pain Link Frequency Relevance Heat
Mechanotransduction 8 96.56 Very High Very High Very High
metalloproteinase 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Advanced Or Metastatic Breast Cancer 1 50.00 Quite Low
Metastasis 23 46.56 Quite Low
Cancer 46 6.48 Low Low
Breast Cancer 6 5.00 Very Low Very Low Very Low
Bone Cancer 6 5.00 Very Low Very Low Very Low
Hypercalcemia 5 5.00 Very Low Very Low Very Low
Osteolysis 3 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 3 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Osteoporosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of actomyosin contractility by blebbistatin and inhibition of ROCK-I by Y-27632 induced a significant decrease in PTHrP mRNA expression in both MDA-MB-231 and RWGT2 cells (Figure 4B), suggesting that the upregulation of PTHrP on rigid substrates is mediated by ROCK.
ROCK Positive_regulation (mediated) of Positive_regulation (upregulation) of PTHrP in MDA-MB-231
1) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0 Pain Relevance 0.12

General Comments

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