INT343544

Context Info Confidence 0.24 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.53 Pain Relevance 0.03

intracellular (GLI2, PTHLH) cytoplasm (GLI2, PTHLH) nucleus (GLI2, PTHLH) cell differentiation (GLI2) Golgi apparatus (PTHLH) cilium (GLI2)

GLI2 (Homo sapiens) PTHLH (Homo sapiens)

Pain Link Frequency Relevance Heat Mechanotransduction 8 58.80 metalloproteinase 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Osteolysis 3 99.80 Metastasis 23 97.76 Cancer 46 79.52 Hypertension 1 73.00 Heart Disease 1 67.64 Breast Cancer 6 53.76 Advanced Or Metastatic Breast Cancer 1 50.00 Stress 2 32.96 Bone Cancer 6 5.00 Hypercalcemia 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Preclinical studies have indicated that inhibiting Gli2 activity reduces PTHrP expression and osteolysis [48].

Negative_regulation (inhibiting) of Gli2 Negative_regulation (reduces) of Gene_expression (expression) of PTHrP associated with osteolysis

1) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.53 Pain Relevance 0.03

General Comments

This test has worked.