INT343545

Context Info Confidence 0.07 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.65 Pain Relevance 0.03

cytoplasm (GLI2, ROCK1) cell differentiation (GLI2) Golgi apparatus (ROCK1) intracellular (GLI2) cilium (GLI2) cell proliferation (GLI2)

GLI2 (Homo sapiens) ROCK1 (Homo sapiens)

Pain Link Frequency Relevance Heat Mechanotransduction 8 64.36 metalloproteinase 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Metastasis 23 99.24 Osteolysis 3 88.88 Cancer 46 85.08 Hypertension 1 78.56 Heart Disease 1 73.20 Breast Cancer 6 59.32 Advanced Or Metastatic Breast Cancer 1 50.00 Stress 2 22.24 Bone Cancer 6 5.00 Hypercalcemia 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus Gli2 may be a potentially more useful target than ROCK for treating bone metastases in the clinic.

Gli2 Binding (target) of ROCK associated with metastasis

1) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.65 Pain Relevance 0.03

General Comments

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