INT343546

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.16
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 3.28
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (ROCK1, PTHLH) cytoplasm (ROCK1, PTHLH) intracellular (PTHLH)
cell-cell signaling (PTHLH) cytosol (ROCK1) signal transduction (ROCK1)
ROCK1 (Homo sapiens)
PTHLH (Homo sapiens)
Pain Link Frequency Relevance Heat
Mechanotransduction 40 51.64 Quite High
metalloproteinase 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteolysis 15 95.40 Very High Very High Very High
Metastasis 115 90.60 High High
Cancer 230 89.92 High High
Bone Cancer 30 86.64 High High
Advanced Or Metastatic Breast Cancer 5 75.00 Quite High
Disease 10 70.92 Quite High
Breast Cancer 30 69.68 Quite High
Hypertension 5 65.84 Quite High
Heart Disease 5 60.48 Quite High
Stress 10 51.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of ROCK using both pharmacological and genetic models decreased PTHrP expression.
Negative_regulation (Inhibition) of ROCK Negative_regulation (decreased) of Gene_expression (expression) of PTHrP
1) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.64 Pain Relevance 0
Furthermore, cells expressing a dominant negative form of the TGF-ß receptor did not respond to substrate rigidity, and inhibition of ROCK decreased PTHrP expression induced by exogenous TGF-ß.
Negative_regulation (inhibition) of ROCK Negative_regulation (decreased) of Gene_expression (expression) of PTHrP
2) Confidence 0.13 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2981576 Disease Relevance 0.81 Pain Relevance 0
Inhibition of Rho-associated kinase (ROCK) using both pharmacological and genetic approaches decreased PTHrP expression.
Negative_regulation (Inhibition) of Rho-associated kinase Negative_regulation (decreased) of Gene_expression (expression) of PTHrP
3) Confidence 0.13 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2981576 Disease Relevance 0.84 Pain Relevance 0
Furthermore, cells expressing a dominant negative form of the TGF-ß receptor did not respond to substrate rigidity, and inhibition of ROCK decreased PTHrP expression induced by exogenous TGF-ß.
Negative_regulation (inhibition) of ROCK Negative_regulation (decreased) of Gene_expression (expression) of PTHrP
4) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.56 Pain Relevance 0
As shown in Figure 6, blocking ROCK either pharmacologically or genetically inhibits most of the incremental PTHrP expression resulting from treatment with exogenous TGF-ß.
Negative_regulation (blocking) of ROCK Negative_regulation (inhibits) of Gene_expression (expression) of PTHrP
5) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.44 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox