INT343547

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Context Info
Confidence 0.15
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.20
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (ROCK1, PTHLH) cytoplasm (ROCK1, PTHLH) intracellular (PTHLH)
cell-cell signaling (PTHLH) cytosol (ROCK1) signal transduction (ROCK1)
Anatomy Link Frequency
MDA-MB-231 2
ROCK1 (Homo sapiens)
PTHLH (Homo sapiens)
Pain Link Frequency Relevance Heat
Mechanotransduction 16 98.68 Very High Very High Very High
metalloproteinase 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 46 85.40 High High
Advanced Or Metastatic Breast Cancer 2 50.00 Quite Low
Cancer 92 5.00 Very Low Very Low Very Low
Breast Cancer 12 5.00 Very Low Very Low Very Low
Bone Cancer 12 5.00 Very Low Very Low Very Low
Hypercalcemia 10 5.00 Very Low Very Low Very Low
Osteolysis 6 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 6 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low
Osteoporosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, ROCK activation leads to increased actomyosin contractility, which led us to question whether the effects of substrate rigidity on PTHrP expression are mediated by ROCK.
ROCK Spec (whether) Positive_regulation (mediated) of Gene_expression (expression) of PTHrP
1) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.14 Pain Relevance 0.08
To further test the hypothesis that modulus effects on PTHrP expression were mediated by ROCK, we pharmacologically inhibited mechanotransduction in MDA-MB-231 and RWGT2 cells on 2 GPa tissue culture polystyrene substrates with blebbistatin or the ROCK inhibitor, Y27632.
ROCK Positive_regulation (mediated) of Gene_expression (expression) of PTHrP in MDA-MB-231 associated with mechanotransduction
2) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.06 Pain Relevance 0.12

General Comments

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