INT343574

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.27
Pain Relevance 2.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (Gys1) cytoplasm (Gys1)
Anatomy Link Frequency
tails 1
olfactory 1
Gys1 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 445 99.88 Very High Very High Very High
Eae 250 99.06 Very High Very High Very High
depression 75 98.48 Very High Very High Very High
antagonist 295 98.30 Very High Very High Very High
Serotonin 100 91.60 High High
5HT 55 88.96 High High
Raphe 5 83.52 Quite High
Endep 50 75.12 Quite High
Hippocampus 10 56.36 Quite High
sSRI 35 49.76 Quite Low
Disease Link Frequency Relevance Heat
Depression 80 98.48 Very High Very High Very High
Neurodegenerative Disease 10 55.36 Quite High
Anxiety Disorder 20 54.04 Quite High
Psychosis 5 25.88 Quite Low
Shock 10 13.28 Low Low
Attention Deficit Hyperactivity Disorder 15 5.00 Very Low Very Low Very Low
Aggression 5 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low
Convulsion 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The 5HT2A/2C receptor antagonist, ritanserin (0.5 mg/kg), was not active in the TST when given alone, and it did not influence the MGS0039 (3 mg/kg)-induced attenuation of immobility time in the TST in mice [F(1,24)?
Neg (not) Gene_expression (influence) of MGS0039 associated with antagonist
1) Confidence 0.04 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2981731 Disease Relevance 0 Pain Relevance 0.34
Secondly, when a modified version of the FST was used to determine the antidepressant-like profile of MGS0039 and LY341495 in rats, i.e., three parameters were measured (climbing, swimming, and immobility), both compounds induced an increase in swimming behavior and a decrease in immobility without affecting the climbing behavior, similar to a reference antidepressant drug, fluvoxamine (Chaki et al. 2004).
Gene_expression (profile) of MGS0039 associated with antidepressant and eae
2) Confidence 0.04 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2981731 Disease Relevance 0.06 Pain Relevance 0.82
This paradigm showed an influence of tested compounds on spontaneous locomotor activity in a new environment, and the treatment schedule was adequate to that used in the TST, where animals were given an MGS0039 injection, and after 30 min, they were hung for 5 min by their tails.
Gene_expression (injection) of MGS0039 in tails associated with eae
3) Confidence 0.04 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2981731 Disease Relevance 0.05 Pain Relevance 0.64
Two-way ANOVA revealed that WAY100635 (0.1 mg/kg) showed the tendency to enhance the non-active dose of MGS0039 (0.3 mg/kg), although the effect was not statistically significant, [F(1,24)?
Gene_expression (revealed) of MGS0039
4) Confidence 0.04 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2981731 Disease Relevance 0 Pain Relevance 0.31
Effects of MGS0039 in the olfactory bulbectomy model of depression
Gene_expression (Effects) of MGS0039 in olfactory associated with depression
5) Confidence 0.04 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2981731 Disease Relevance 0.16 Pain Relevance 0.31

General Comments

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