INT343575

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.15
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (Gys1) cytoplasm (Gys1)
Gys1 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 267 98.04 Very High Very High Very High
Serotonin 60 85.84 High High
depression 45 79.36 Quite High
antagonist 177 77.76 Quite High
Eae 150 61.24 Quite High
5HT 33 57.44 Quite High
sSRI 21 44.96 Quite Low
Endep 30 22.32 Low Low
fluoxetine 3 10.08 Low Low
Glutamate receptor 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 48 79.36 Quite High
Anxiety Disorder 12 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 9 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low
Shock 6 5.00 Very Low Very Low Very Low
Aggression 3 5.00 Very Low Very Low Very Low
Psychosis 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Convulsion 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also, enhanced activity of MGS0039 in the PCPA-pretreated mice is not specifically antidepressant like it seems, but rather a false positive effect, resulting probably from changes in AMPA receptor level.
Positive_regulation (enhanced) of MGS0039 associated with antidepressant
1) Confidence 0.03 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2981731 Disease Relevance 0.15 Pain Relevance 0.50
MGS0039, at a dose of 3 mg/kg, was active in the TST in both control and PCPA-pretreated mice [F(1,26)?
Positive_regulation (active) of MGS0039
2) Confidence 0.03 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2981731 Disease Relevance 0 Pain Relevance 0.40
MGS0039 was not active in the TST at a dose of 0.3 mg/kg.
Neg (not) Positive_regulation (active) of MGS0039
3) Confidence 0.03 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2981731 Disease Relevance 0 Pain Relevance 0.26

General Comments

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