INT34358

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Context Info
Confidence 0.37
First Reported 1987
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 7.25
Pain Relevance 5.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MME) plasma membrane (MME) cell-cell signaling (MME)
Anatomy Link Frequency
neural 2
erythrocyte 1
lymphocytes 1
pia mater 1
glands 1
MME (Homo sapiens)
Pain Link Frequency Relevance Heat
reflex sympathetic dystrophy 16 99.72 Very High Very High Very High
Enkephalin 11 99.44 Very High Very High Very High
bradykinin 36 98.44 Very High Very High Very High
tetrodotoxin 6 97.52 Very High Very High Very High
Spinal cord 5 96.76 Very High Very High Very High
substance P 15 95.52 Very High Very High Very High
Pain 2 94.76 High High
Neuropeptide 11 94.36 High High
substantia gelatinosa 1 94.24 High High
Inflammation 7 93.48 High High
Disease Link Frequency Relevance Heat
Cancer 232 99.60 Very High Very High Very High
Prostate Cancer 52 99.40 Very High Very High Very High
Complex Regional Pain Syndromes 16 99.40 Very High Very High Very High
Rickets 1 94.88 High High
Pain 2 94.76 High High
Neurogenic Inflammation 4 93.92 High High
Injury 2 91.96 High High
Lymphatic System Cancer 168 91.08 High High
Metastasis 52 89.48 High High
Diffuse Large B-cell Lymphoma 56 88.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In all three cases, the cancer glands were mostly negative for CD10.
CD10 Binding (negative) of in glands associated with cancer
1) Confidence 0.37 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 1.26 Pain Relevance 0
Lack of genetic association of neutral endopeptidase (NEP) with complex regional pain syndrome (CRPS).
neutral endopeptidase Binding (association) of associated with complex regional pain syndromes and reflex sympathetic dystrophy
2) Confidence 0.37 Published 2010 Journal Neurosci. Lett. Section Title Doc Link 20105452 Disease Relevance 0.98 Pain Relevance 1.14
Lack of genetic association of neutral endopeptidase (NEP) with complex regional pain syndrome (CRPS).
NEP Binding (association) of associated with complex regional pain syndromes and reflex sympathetic dystrophy
3) Confidence 0.37 Published 2010 Journal Neurosci. Lett. Section Title Doc Link 20105452 Disease Relevance 0.98 Pain Relevance 1.14
Neutral endopeptidase (NEP/CD10) is a cell surface zinc metalloprotease cleaving peptide bounds on the amino terminus of hydrophobic amino acids and inactivating multiple physiologically active peptides.
NEP Binding (bounds) of
4) Confidence 0.36 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17294442 Disease Relevance 0.56 Pain Relevance 0
Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon.
Neprilysin Binding (complexed) of
5) Confidence 0.36 Published 2000 Journal J. Mol. Biol. Section Title Doc Link 10669592 Disease Relevance 0.25 Pain Relevance 0.29
Albrecht et al. [19] have reported a shift from membrane bound to cytoplasmic localization for CD10 in high-grade prostate cancer cells with a loss of CD10 expression in areas of high proliferative activity as indicated by Ki67 immunohistochemistry (n = 24, with perhaps around 7 containing CD10+ cancer cells based on their frequency).
CD10 Binding (bound) of associated with cancer and prostate cancer
6) Confidence 0.35 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 0.81 Pain Relevance 0
To determine the mechanisms of BK-induced airway narrowing, we investigated the effects of epithelium removal, inhibition of the enzymes neutral endopeptidase (NEP) and cyclooxygenase, and blockade of neural conductance with tetrodotoxin (TTX) on BK-induced responses of human isolated peripheral airways.
NEP Neg (inhibition) Binding (inhibition) of in neural associated with tetrodotoxin and bradykinin
7) Confidence 0.34 Published 1994 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 7921430 Disease Relevance 0.09 Pain Relevance 0.66
Our publication in 1984 dealt with ACE and NEP purified to homogeneity from human kidney.
NEP Binding (dealt) of in kidney
8) Confidence 0.31 Published 2004 Journal Peptides Section Abstract Doc Link 15134871 Disease Relevance 0 Pain Relevance 0.37
To determine the mechanisms of BK-induced airway narrowing, we investigated the effects of epithelium removal, inhibition of the enzymes neutral endopeptidase (NEP) and cyclooxygenase, and blockade of neural conductance with tetrodotoxin (TTX) on BK-induced responses of human isolated peripheral airways.
neutral endopeptidase Neg (inhibition) Binding (inhibition) of in neural associated with tetrodotoxin and bradykinin
9) Confidence 0.30 Published 1994 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 7921430 Disease Relevance 0.09 Pain Relevance 0.66
Enzymatic studies using [3H][D-Ala2, Leu]enkephalin as substrate confirmed the presence of NEP in dura and pia mater of human tissue.
NEP Binding (presence) of in pia mater associated with enkephalin
10) Confidence 0.28 Published 1987 Journal FEBS Lett. Section Abstract Doc Link 3034668 Disease Relevance 0 Pain Relevance 0.47
Two other mammalian gene products exhibit strong homology with NEP: the erythrocyte cell-surface antigen, KELL; and the putative product of the PEX gene, which has been associated with X-linked hypophosphatemic rickets.
NEP Binding (homology) of in erythrocyte associated with rickets
11) Confidence 0.26 Published 1997 Journal FASEB J. Section Abstract Doc Link 9141502 Disease Relevance 0.16 Pain Relevance 0.11
The lymphocytes express B-cell markers (CD19, CD20, and CD79a) and are negative for CD3, CD5, CD10, CD23, and cyclin D1.
CD10 Binding (negative) of in lymphocytes
12) Confidence 0.12 Published 2008 Journal J Hematop Section Body Doc Link PMC2713483 Disease Relevance 1.47 Pain Relevance 0.26
Uccella et al. used the most common approach with CD10, Bcl-2, BCL6, and MUM1 antibodies in 71 patients and could not find prognostic relevance, although BCL6 expression as single marker was [61].
CD10 Binding (approach) of
13) Confidence 0.07 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.61 Pain Relevance 0.03

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