INT343644

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Grm5, Cav2) plasma membrane (Grm5, Cav2) Golgi apparatus (Cav2)
mitochondrion organization (Cav2) intracellular (Cav2) protein complex (Cav2)
Anatomy Link Frequency
pyramidal neurons 1
Grm5 (Mus musculus)
Cav2 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 14 99.60 Very High Very High Very High
Pyramidal cell 15 98.68 Very High Very High Very High
Glutamate 7 97.62 Very High Very High Very High
Action potential 22 77.92 Quite High
addiction 8 35.28 Quite Low
Glutamate receptor 6 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
Neuronal excitability 3 5.00 Very Low Very Low Very Low
conotoxin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 7 41.52 Quite Low
Disease 2 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Intellectual Impairment 1 5.00 Very Low Very Low Very Low
Neurological Disease 1 5.00 Very Low Very Low Very Low
Epilepsy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The findings reported here suggest that activation of group I mGluRs, which can occur as a result of synaptically released glutamate, increases the excitability of CA1 pyramidal neurons primarily by converting the post-spike AHP to an ADP via group I mGluR-mediated upregulation of Cav2.3 R-type calcium channels.
mGluR Positive_regulation (upregulation) of Cav2 in pyramidal neurons associated with glutamate, calcium channel and pyramidal cell
1) Confidence 0.05 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.19

General Comments

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