INT3437

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Context Info
Confidence 0.48
First Reported 1978
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.66
Pain Relevance 2.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Bad) cell proliferation (Bad) cytosol (Bad)
mitochondrion (Bad) cytoplasm (Bad)
Bad (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 9 100.00 Very High Very High Very High
Analgesic 10 99.38 Very High Very High Very High
COX-2 inhibitor 8 98.44 Very High Very High Very High
Potency 1 98.00 Very High Very High Very High
Morphine 8 97.40 Very High Very High Very High
tolerance 1 93.32 High High
withdrawal 3 89.24 High High
narcan 1 81.20 Quite High
antagonist 2 80.48 Quite High
Opioid 2 80.00 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 11 96.32 Very High Very High Very High
Infarction 4 92.92 High High
Death 3 90.68 High High
Myocardial Infarction 15 88.80 High High
INFLAMMATION 4 87.76 High High
Cancer 10 75.00 Quite High
Lymphatic System Cancer 1 63.44 Quite High
Renal Cancer 1 62.32 Quite High
Malignant Neoplastic Disease 1 41.60 Quite Low
Hypertrophy 1 38.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Concurrently, a down-regulation of the proapoptotic proteins FasL and Bad was detected in cortical lysates.
Negative_regulation (regulation) of Bad
1) Confidence 0.48 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16496378 Disease Relevance 0.53 Pain Relevance 0.56
Western blotting showed that a single injection of naltrexone (1 mg/kg) induced a down-regulation of the pro-apototic proteins Fas, FasL, Bad and Bax.
Negative_regulation (down-regulation) of Bad
2) Confidence 0.41 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16716514 Disease Relevance 0.24 Pain Relevance 0.27
On the other hand, the analgesic activity of M73101 as well as BAD was decreased by repeated oral administration in mice, and the potency was weaker than mepirizole.
Negative_regulation (decreased) of BAD associated with analgesic, cinod and potency
3) Confidence 0.27 Published 1978 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 744551 Disease Relevance 0.23 Pain Relevance 1.60
Some of the COX-independent mechanisms for NSAIDs and selective COX-2 inhibitors include activation of protein kinase G, inhibition of NF-kappa B activation, downregulation of the antiapoptotic protein Bcl-XL, inhibition of PPAR delta, and activation of PPAR gamma.
Negative_regulation (downregulation) of antiapoptotic protein Bcl-XL associated with cinod and cox-2 inhibitor
4) Confidence 0.06 Published 2003 Journal Prog Exp Tumor Res Section Abstract Doc Link 12795055 Disease Relevance 0.47 Pain Relevance 0.53
This is likely due to EIIa promoter suppression in the differentiating cells.
Negative_regulation (suppression) of EIIa promoter
5) Confidence 0.01 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064849 Disease Relevance 0.18 Pain Relevance 0.03

General Comments

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