INT34370

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Context Info
Confidence 0.46
First Reported 1987
Last Reported 2010
Negated 4
Speculated 2
Reported most in Abstract
Documents 26
Total Number 34
Disease Relevance 15.21
Pain Relevance 6.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cfp)
Anatomy Link Frequency
SRBC 3
PFC 3
forebrain 2
spleen 1
adrenal gland 1
Cfp (Mus musculus)
Pain Link Frequency Relevance Heat
depression 178 100.00 Very High Very High Very High
Hippocampus 47 100.00 Very High Very High Very High
amygdala 9 100.00 Very High Very High Very High
Glutamate 9 99.84 Very High Very High Very High
Morphine 8 99.84 Very High Very High Very High
projection neuron 1 99.24 Very High Very High Very High
Catecholamine 30 99.14 Very High Very High Very High
dopamine receptor 2 98.60 Very High Very High Very High
mu opioid receptor 17 98.50 Very High Very High Very High
Locus ceruleus 4 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Poisoning 1739 100.00 Very High Very High Very High
Depression 189 100.00 Very High Very High Very High
Toxicity 259 99.96 Very High Very High Very High
Suicidal Behaviour 8 99.44 Very High Very High Very High
Immunization 50 99.36 Very High Very High Very High
Ciguatera Poisoning 432 97.94 Very High Very High Very High
Anxiety Disorder 37 96.08 Very High Very High Very High
Shock 5 94.96 High High
Affective Disorder 10 93.20 High High
Sprains And Strains 117 92.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The enhancement of PFC by epinephrine was completely blocked by preadministration with propranolol and hexamethonium, but not with phentolamine.
Positive_regulation (enhancement) of PFC
1) Confidence 0.46 Published 1987 Journal J. Immunol. Section Abstract Doc Link 3035011 Disease Relevance 0.16 Pain Relevance 0.12
In normal mice, the enhancement of PFC was observed 2 hr after one physical stimulation.
Positive_regulation (enhancement) of PFC
2) Confidence 0.46 Published 1987 Journal J. Immunol. Section Abstract Doc Link 3035011 Disease Relevance 0.16 Pain Relevance 0.11
The enhancement of anti-SRBC PFC by s.c. injection of epinephrine suggested that the autonomic nervous system, especially the sympathetic nervous system, was activated by a local stimulus effect of the injection.
Positive_regulation (enhancement) of PFC in autonomic nervous system
3) Confidence 0.46 Published 1987 Journal J. Immunol. Section Abstract Doc Link 3035011 Disease Relevance 0.14 Pain Relevance 0.11
The anti-SRBC PFC from mice immunized with 5 X 10(7) SRBC was markedly increased by daily s.c. injections of epinephrine.
Positive_regulation (increased) of PFC in SRBC
4) Confidence 0.46 Published 1987 Journal J. Immunol. Section Abstract Doc Link 3035011 Disease Relevance 0.15 Pain Relevance 0.12
In the PrPFC, eCB-LTD did not require the activation of NMDAR, D1 or D2 dopamine receptors, as demonstrated by the lack of effects of a cocktail of antagonist of these receptors (Fig 5A).
Neg (not) Positive_regulation (require) of PrPFC associated with depression, antagonist and dopamine receptor
5) Confidence 0.31 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0.75 Pain Relevance 0.72
The enhancement of PFC by physical stimuli was observed in nonimmunized mice when spleen cells from stimulated mice were cultured with SRBC in vitro.
Positive_regulation (enhancement) of PFC in SRBC
6) Confidence 0.31 Published 1987 Journal J. Immunol. Section Abstract Doc Link 3035011 Disease Relevance 0.17 Pain Relevance 0.11
The enhancement of PFC by these stimuli was completely blocked by preadministration with propranolol and hexamethonium.
Positive_regulation (enhancement) of PFC
7) Confidence 0.31 Published 1987 Journal J. Immunol. Section Abstract Doc Link 3035011 Disease Relevance 0.17 Pain Relevance 0.11
The PFC was increased by osmotic and physical stimuli given once a day for 4 days after immunization with SRBC.
Positive_regulation (increased) of PFC in SRBC associated with immunization
8) Confidence 0.31 Published 1987 Journal J. Immunol. Section Abstract Doc Link 3035011 Disease Relevance 0.17 Pain Relevance 0.12
However, spleen cells from mice given two physical stimuli did not show the enhancement of PFC after treatment with anti-Thy-1.2 antibody and complement, nor after removal of nonadherent cells.
Positive_regulation (enhancement) of PFC in spleen
9) Confidence 0.31 Published 1987 Journal J. Immunol. Section Abstract Doc Link 3035011 Disease Relevance 0.16 Pain Relevance 0.10
Effects of catecholamines and osmotical and physical stimuli on the induction of anti-sheep red blood cells (SRBC) plaque-forming cells (PFC) were investigated in (C57BL/6 X BALB/c)F1 mice in vivo and in vitro.
Positive_regulation (induction) of PFC in plaque associated with catecholamine
10) Confidence 0.31 Published 1987 Journal J. Immunol. Section Abstract Doc Link 3035011 Disease Relevance 0.14 Pain Relevance 0.12
This enhancement of anti-SRBC PFC appear to be due to the activation of antigen non-specific helper T lymphocytes by the beta-actin of endogenous catecholamines from the adrenal gland.
Positive_regulation (enhancement) of PFC in adrenal gland associated with catecholamine
11) Confidence 0.31 Published 1987 Journal J. Immunol. Section Abstract Doc Link 3035011 Disease Relevance 0.14 Pain Relevance 0.12
Indeed, YFP-increases and concomitant CFP-decreases were observed in initial experiments on rat organotypic hippocampal slices, in which increasing number of synaptic shocks were delivered to the mossy fibers and fluorescence changes were recorded in the neuropil of the CA3 region (Figure 3A).
Positive_regulation (increases) of CFP in neuropil associated with shock
12) Confidence 0.26 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2866455 Disease Relevance 0.09 Pain Relevance 0.07
We found that it is possible to induce eCB-LTD in the PrPFC by applying subthreshold stimulation in the presence of blockers of either eCBs reuptake (AM404) or 2-AG degradation [39], [40].
Spec (possible) Positive_regulation (induce) of PrPFC associated with depression
13) Confidence 0.25 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0.22 Pain Relevance 0.14
Moreover, in contrast to white noise exposure, BDNF expression levels in the prefrontal cortex (PFC), amygdala and hippocampus were significantly increased in music-exposed adult BDNF(Met/Met) mice.
Positive_regulation (increased) of PFC in PFC associated with hippocampus and amygdala
14) Confidence 0.19 Published 2010 Journal Brain Res. Section Abstract Doc Link 20515664 Disease Relevance 0.94 Pain Relevance 0.35
However, music treatment could not upregulate BDNF levels in the PFC, amygdala, and hippocampus in BDNF(+/)(-) mice, which suggests the essential role of BDNF in the anxiolytic effect of music.
Neg (not) Positive_regulation (upregulate) of PFC in amygdala associated with anxiety disorder, hippocampus and amygdala
15) Confidence 0.19 Published 2010 Journal Brain Res. Section Abstract Doc Link 20515664 Disease Relevance 0.91 Pain Relevance 0.35
All these methods show good results for the determination of CTXs at levels that can cause CFP in humans.
Positive_regulation (cause) of CFP associated with poisoning
16) Confidence 0.19 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.44 Pain Relevance 0
In our recent study (Xu et al., 2009), a lower spontaneous alternation in the Y-maze was found in CPZ-treated mice starting from 14th day after CPZ treatment when DA levels increased in PFC and remained throughout the whole 6-weeks experimental period.
Positive_regulation (increased) of PFC
17) Confidence 0.16 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2842101 Disease Relevance 0.05 Pain Relevance 0.04
CFP toxins accumulate mainly in the viscera of fish, but are also present in the muscle and other parts of the body [31,35].
Positive_regulation (accumulate) of CFP in body associated with poisoning
18) Confidence 0.16 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 1.20 Pain Relevance 0.07
On the other hand, a small population of mu-opioid receptors is located on PFC projection neurons [40] so deletion of the Oprm1 gene could increase PFC activity by directly removing this inhibitory input.
Positive_regulation (uld incr) of PFC in PFC associated with mu opioid receptor and projection neuron
19) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635474 Disease Relevance 0.35 Pain Relevance 0.71
Critical analysis and availability of methodologies for CTX determination is required for a rapid response to suspected CFP cases and to conduct sound CFP risk analysis.


1.

Positive_regulation (response) of CFP associated with poisoning
20) Confidence 0.14 Published 2010 Journal Marine Drugs Section Abstract Doc Link PMC2901828 Disease Relevance 0.80 Pain Relevance 0

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