INT343834

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.08
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6) extracellular space (CD14) extracellular region (CD14)
nucleus (IRF6) plasma membrane (CD14) DNA binding (IRF6)
Anatomy Link Frequency
MD2 1
liver 1
CD14 (Homo sapiens)
IRF6 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 108 100.00 Very High Very High Very High
Bile 10 99.36 Very High Very High Very High
cytokine 94 98.52 Very High Very High Very High
alcohol 8 96.88 Very High Very High Very High
Inflammation 132 87.40 High High
ischemia 8 84.80 Quite High
Inflammatory response 30 61.56 Quite High
tolerance 14 48.76 Quite Low
Inflammatory mediators 6 34.16 Quite Low
fibrosis 36 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 62 95.60 Very High Very High Very High
Stress 18 89.28 High High
INFLAMMATION 160 87.40 High High
Alzheimer's Dementia 4 85.80 High High
Cv Unclassified Under Development 6 84.80 Quite High
Hepatotoxicity 6 84.12 Quite High
Reperfusion Injury 22 84.08 Quite High
Endotoxemia 4 81.84 Quite High
Alcoholic Liver Diseases 4 81.32 Quite High
Adhesions 14 80.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding of LPS to CD14/TLR4 on KCs activates production of cytokines and oxidants, primary mediators of early ethanol-induced liver injury.
CD14 Binding (Binding) of LPS in liver associated with injury, agonist and cytokine
1) Confidence 0.02 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 1.04 Pain Relevance 0.50
The uptake of LPS by hepatocytes in vivo is through a CD14-TLR4-MD2-dependent mechanism, and is mediated by ?
CD14 Binding (mechanism) of LPS in MD2 associated with agonist
2) Confidence 0.02 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 1.03 Pain Relevance 0.40

General Comments

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