INT343838

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Context Info
Confidence 0.11
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.87
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EDA, TLR4) plasma membrane (EDA, TLR4) pigmentation (EDA)
cell differentiation (EDA) extracellular region (EDA) intracellular (TLR4)
Anatomy Link Frequency
MD2 1
EDA (Homo sapiens)
TLR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 94 99.56 Very High Very High Very High
Inflammation 132 90.68 High High
chemokine 20 60.84 Quite High
Inflammatory response 30 56.80 Quite High
agonist 108 5.00 Very Low Very Low Very Low
fibrosis 36 5.00 Very Low Very Low Very Low
tolerance 14 5.00 Very Low Very Low Very Low
Bile 10 5.00 Very Low Very Low Very Low
metalloproteinase 10 5.00 Very Low Very Low Very Low
alcohol 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 160 90.68 High High
Pathologic Processes 2 88.40 High High
Injury 62 82.84 Quite High
Edema 2 50.16 Quite High
Sepsis 10 29.12 Quite Low
Hepatotoxicity 6 28.16 Quite Low
Shock 4 18.00 Low Low
Disease 16 8.20 Low Low
Cirrhosis 122 5.00 Very Low Very Low Very Low
Fibrosis 48 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recombinant EDA, but not other recombinant fibronectin domains, activates human TLR4 expressed in a cell type (HEK293) that normally lacks this TLR.
Recombinant EDA Positive_regulation (activates) of TLR4
1) Confidence 0.11 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.44 Pain Relevance 0.24
EDA stimulation of TLR4 is dependent upon co-expression of MD2, a TLR4 accessory protein [48].


EDA Positive_regulation (stimulation) of TLR4 in MD2
2) Confidence 0.11 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.43 Pain Relevance 0.26

General Comments

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