INT343846

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.29
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK1, FOS) nucleus (MAPK1, FOS) mitochondrion (MAPK1)
aging (FOS) Golgi apparatus (MAPK1) DNA binding (MAPK1)
MAPK1 (Homo sapiens)
FOS (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 94 87.04 High High
Inflammation 132 86.64 High High
metalloproteinase 10 72.32 Quite High
agonist 108 5.00 Very Low Very Low Very Low
fibrosis 36 5.00 Very Low Very Low Very Low
Inflammatory response 30 5.00 Very Low Very Low Very Low
chemokine 20 5.00 Very Low Very Low Very Low
tolerance 14 5.00 Very Low Very Low Very Low
Bile 10 5.00 Very Low Very Low Very Low
alcohol 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cirrhosis 122 98.08 Very High Very High Very High
Stress 18 93.68 High High
Viral Infection 4 88.36 High High
INFLAMMATION 160 86.64 High High
Fibrosis 48 79.84 Quite High
Injury 62 50.00 Quite Low
Apoptosis 26 44.84 Quite Low
Death 2 16.44 Low Low
Hepatocellular Cancer 2 6.92 Low Low
Infection 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These stimuli activate MAPK cascades by phosphorylating distinct substrates, mostly for p38, Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK), which enhance AP-1 activity.
extracellular signal-regulated kinase Positive_regulation (enhance) of AP-1
1) Confidence 0.04 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.65 Pain Relevance 0.22
These stimuli activate MAPK cascades by phosphorylating distinct substrates, mostly for p38, Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK), which enhance AP-1 activity.
ERK Positive_regulation (enhance) of AP-1
2) Confidence 0.04 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.64 Pain Relevance 0.22

General Comments

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