INT343851

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.96
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (IRF6, TLR4) cytosol (IRF6) signal transduction (TLR4)
plasma membrane (TLR4) intracellular (TLR4) nucleus (IRF6)
Anatomy Link Frequency
liver 2
IRF6 (Homo sapiens)
TLR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 54 100.00 Very High Very High Very High
chemokine 10 93.76 High High
cytokine 47 93.16 High High
Inflammatory response 15 89.28 High High
fibrosis 18 85.60 High High
Inflammation 66 84.16 Quite High
Bile 5 84.00 Quite High
tolerance 7 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Hepatitis 2 99.48 Very High Very High Very High
Cirrhosis 61 98.32 Very High Very High Very High
Liver Disease 6 96.04 Very High Very High Very High
INFLAMMATION 80 88.92 High High
Injury 31 86.48 High High
Fibrosis 24 85.60 High High
Chronic Disease 2 72.04 Quite High
Keloid Scars 2 71.28 Quite High
Sprains And Strains 1 70.24 Quite High
Infection 12 69.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LPS and endogenous TLR4 ligands are increased in the serum and livers of patients with liver cirrhosis and of animals with experimental chronic liver disease.
Positive_regulation (increased) of LPS Binding (ligands) of TLR4 in liver associated with liver disease, cirrhosis and agonist
1) Confidence 0.07 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 1.96 Pain Relevance 0.66

General Comments

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