INT343857

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.96
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ABCC8, LY96) extracellular space (LY96) extracellular region (LY96)
small molecule metabolic process (ABCC8) ATPase activity (ABCC8) carbohydrate metabolic process (ABCC8)
Anatomy Link Frequency
MD2 1
ABCC8 (Homo sapiens)
LY96 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 47 89.60 High High
Inflammation 66 88.96 High High
Inflammatory response 15 82.80 Quite High
chemokine 10 57.12 Quite High
agonist 54 5.00 Very Low Very Low Very Low
fibrosis 18 5.00 Very Low Very Low Very Low
tolerance 7 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 5 92.64 High High
Hepatotoxicity 3 91.68 High High
INFLAMMATION 80 88.96 High High
Edema 1 80.16 Quite High
Disease 8 71.72 Quite High
Injury 31 50.00 Quite Low
Necrosis 4 32.16 Quite Low
Apoptosis 13 26.24 Quite Low
Cirrhosis 61 5.00 Very Low Very Low Very Low
Fibrosis 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using phagocytes obtained from mice expressing a non-functional TLR4 mutant protein, and HEK293 cells (human embryonic kidney cells) replaced with exogenous expression of TLR4, MRP8 was demonstrated to interact specifically with the TLR-MD2 complex, thus representing an endogenous ligand of TLR4 [59].


MRP8 Binding (interact) of MD2 in MD2
1) Confidence 0.02 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.96 Pain Relevance 0.34

General Comments

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