INT343864

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Context Info
Confidence 0.11
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.44
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EDA, TLR4) plasma membrane (EDA, TLR4) pigmentation (EDA)
cell differentiation (EDA) extracellular region (EDA) intracellular (TLR4)
EDA (Homo sapiens)
TLR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 47 99.56 Very High Very High Very High
Inflammation 66 90.68 High High
chemokine 10 60.84 Quite High
Inflammatory response 15 56.80 Quite High
agonist 54 5.00 Very Low Very Low Very Low
fibrosis 18 5.00 Very Low Very Low Very Low
tolerance 7 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 80 90.68 High High
Pathologic Processes 1 88.40 High High
Injury 31 82.84 Quite High
Edema 1 50.16 Quite High
Sepsis 5 29.12 Quite Low
Hepatotoxicity 3 28.16 Quite Low
Shock 2 11.76 Low Low
Disease 8 8.20 Low Low
Cirrhosis 61 5.00 Very Low Very Low Very Low
Fibrosis 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recombinant EDA, but not other recombinant fibronectin domains, activates human TLR4 expressed in a cell type (HEK293) that normally lacks this TLR.
Recombinant EDA Positive_regulation (activates) of Gene_expression (expressed) of TLR4
1) Confidence 0.11 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.44 Pain Relevance 0.25

General Comments

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