INT343891

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.23
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.30
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRAK1) signal transduction (IRAK1) plasma membrane (IRAK1)
nucleus (IRAK1) kinase activity (IRAK1) cytoplasm (IRAK1)
Anatomy Link Frequency
biliary epithelium 2
IRAK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory marker 2 100.00 Very High Very High Very High
tolerance 14 99.74 Very High Very High Very High
antagonist 4 88.24 High High
cytokine 94 71.68 Quite High
chemokine 20 67.48 Quite High
Inflammatory mediators 6 55.92 Quite High
Inflammatory response 30 49.60 Quite Low
agonist 108 46.80 Quite Low
fibrosis 36 27.48 Quite Low
Inflammation 132 21.88 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 160 100.00 Very High Very High Very High
Infection 24 93.16 High High
Adhesions 14 53.44 Quite High
Injury 62 50.00 Quite Low
Endotoxemia 4 32.44 Quite Low
Stress 18 30.12 Quite Low
Fibrosis 48 27.48 Quite Low
Cirrhosis 122 22.64 Low Low
Obesity 14 20.72 Low Low
Shock 4 11.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This effect is mediated through the TLR4-PI3K-AKT signaling pathway, as the induction of inflammatory markers was also inhibited by a dominant-negative mutant of TLR4, MyD88, IRAK-1, TRAF6 or I?
Positive_regulation (mediated) of Gene_expression (mutant) of IRAK-1 associated with inflammatory marker
1) Confidence 0.23 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.21 Pain Relevance 0.19
The tolerance is possibly induced by the expression of IRAK-M in the intrahepatic biliary epithelium [78].


Spec (possibly) Positive_regulation (induced) of Gene_expression (expression) of IRAK in biliary epithelium associated with tolerance
2) Confidence 0.23 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.09 Pain Relevance 0.24

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox