INT3439

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Context Info
Confidence 0.78
First Reported 1977
Last Reported 2010
Negated 2
Speculated 14
Reported most in Abstract
Documents 1017
Total Number 1032
Disease Relevance 112.39
Pain Relevance 727.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Abat)
Anatomy Link Frequency
neurons 67
brain 37
striatum 27
hippocampus 27
interneurons 25
Abat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 10936 100.00 Very High Very High Very High
Glutamate 3451 100.00 Very High Very High Very High
Dopamine 3117 100.00 Very High Very High Very High
antagonist 2512 100.00 Very High Very High Very High
agonist 2077 100.00 Very High Very High Very High
Neurotransmitter 1336 100.00 Very High Very High Very High
opioid receptor 482 100.00 Very High Very High Very High
Enkephalin 427 100.00 Very High Very High Very High
substance P 389 100.00 Very High Very High Very High
Serotonin 373 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 287 100.00 Very High Very High Very High
Depression 516 99.92 Very High Very High Very High
Pain 615 99.84 Very High Very High Very High
Cv Unclassified Under Development 453 99.84 Very High Very High Very High
Neuropathic Pain 415 99.84 Very High Very High Very High
Urological Neuroanatomy 623 99.68 Very High Very High Very High
Convulsion 480 99.56 Very High Very High Very High
Targeted Disruption 209 99.56 Very High Very High Very High
Stress 963 99.54 Very High Very High Very High
Pressure And Volume Under Development 89 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regional differences in nerve terminal Na+ channel subtype expression and Na+ channel-dependent glutamate and GABA release in rat CNS.
Localization (release) of GABA in nerve associated with gaba and glutamate
1) Confidence 0.78 Published 2010 Journal J. Neurochem. Section Title Doc Link 20374421 Disease Relevance 0 Pain Relevance 0.97
However, the efficacies of TTX for inhibition of 4AP-evoked glutamate release were greater than for inhibition of GABA release in all regions except spinal cord.
Localization (release) of GABA in spinal cord associated with tetrodotoxin, gaba, glutamate and spinal cord
2) Confidence 0.78 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20374421 Disease Relevance 0 Pain Relevance 1.08
The findings suggest that Enk and GABA are released from the same or convergent terminals and co-regulate the activity of common target neurons within the rat VTA.
Localization (released) of GABA in neurons associated with ventral tegmentum, gaba and enkephalin
3) Confidence 0.77 Published 1995 Journal Brain Res. Section Abstract Doc Link 7538419 Disease Relevance 0.09 Pain Relevance 0.87
These findings are consistent with the proposed mechanism of action of morphine in the lateral ventrocaudal PAG and offer the first direct evidence that systemic opiates decrease GABA release in this midbrain region.
Localization (release) of GABA in midbrain associated with gaba, midbrain, opiate, central grey and morphine
4) Confidence 0.75 Published 1992 Journal Brain Res. Section Abstract Doc Link 1450948 Disease Relevance 0.54 Pain Relevance 1.13
The findings suggest that GABA receptors located in the PF may mediate the antinociceptive response to GABAergic drugs, and that the action of these agents is unrelated to opiate receptors.
Localization (located) of GABA associated with gabaergic, gaba receptor, opiate and antinociceptive
5) Confidence 0.72 Published 1986 Journal Brain Res. Section Abstract Doc Link 3021277 Disease Relevance 0 Pain Relevance 1.10
This indicates that GABA release can involve an indirect, TTX-sensitive mechanism.
Localization (release) of GABA associated with tetrodotoxin and gaba
6) Confidence 0.71 Published 2010 Journal J. Neuroendocrinol. Section Abstract Doc Link 20236227 Disease Relevance 0.14 Pain Relevance 1.56
In the presence of tetrodotoxin (TTX), the cannabinoid CB1 receptor agonist WIN 55,212-2 inhibited K(+)-evoked GABA release.
Localization (release) of GABA associated with tetrodotoxin, gaba, cannabinoid and agonist
7) Confidence 0.71 Published 2010 Journal J. Neuroendocrinol. Section Abstract Doc Link 20236227 Disease Relevance 0.16 Pain Relevance 1.32
Clozapine (5.0 mg/kg) increased GABA release in the fundus striati and haloperidol (0.5 mg/kg) increased GABA release in the globus pallidus.
Localization (release) of GABA in fundus associated with gaba
8) Confidence 0.71 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2073921 Disease Relevance 0 Pain Relevance 0.50
The value for GABA release is probably not valid since it fell outside of the linear part of the regression line which was used for calculation.
Localization (release) of GABA associated with gaba
9) Confidence 0.71 Published 1981 Journal Anesthesiology Section Abstract Doc Link 7247056 Disease Relevance 0 Pain Relevance 0.89
The effects of midazolam, a water-soluble benzodiazepine, on GABA disposal (14CO2 from [1-14C]GABA) and on the individual processes of GABA uptake, GABA release, and GABA-transaminase in the rat brain synaptosomal model system were studied.
Localization (release) of GABA-transaminase in brain associated with gaba and versed
10) Confidence 0.71 Published 1981 Journal Anesthesiology Section Abstract Doc Link 7247056 Disease Relevance 0 Pain Relevance 0.75
L-Aspartic acid only reduced the GABA release, whereas kainic acid exhibited only a marked enhancement of its release.
Localization (release) of GABA associated with gaba
11) Confidence 0.71 Published 1981 Journal Brain Res. Section Abstract Doc Link 6118201 Disease Relevance 0 Pain Relevance 0.41
These data indicate that GABA release from striatopallidal neurons is regulated through A(2A) receptors in both the striatum and globus pallidus.
Localization (release) of GABA in globus pallidus associated with gaba
12) Confidence 0.71 Published 2000 Journal Neuroscience Section Abstract Doc Link 10996458 Disease Relevance 0 Pain Relevance 0.70
Also, comparatively less GABA release could be evoked from nigral than from cortical slices by K+ concentrations between 15 and 25 mmol/l.
Localization (release) of GABA associated with gaba
13) Confidence 0.71 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2555718 Disease Relevance 0 Pain Relevance 0.43
Characterization of GABA release from intrastriatal striatal transplants: dependence on host-derived afferents.
Localization (release) of GABA associated with addiction and gaba
14) Confidence 0.71 Published 1993 Journal Neuroscience Section Title Doc Link 8098510 Disease Relevance 0 Pain Relevance 0.45
These results suggest that GABA decreases the response to EFS by directly inhibiting the evoked release of ACh through GABA(B) receptors in rat trachea and that STZ-induced diabetes causes an impairment in the inhibitory effect of GABA on neurally induced contractions in this tissue.
Localization (release) of GABA in trachea associated with gaba and diabetes mellitus
15) Confidence 0.70 Published 2000 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 10779129 Disease Relevance 0.47 Pain Relevance 0.83
Altogether, these results suggest that reduction of the depolarization-evoked GABA release might contribute to thiopental anesthesia, but this seems unlikely for volatile anesthetics.
Localization (release) of GABA associated with anesthesia and gaba
16) Confidence 0.70 Published 1995 Journal Brain Res. Section Abstract Doc Link 7743195 Disease Relevance 0 Pain Relevance 0.67
Hypothalamic superfusion with a potassium-rich (50 or 90 mmol/l) artificial cerebrospinal fluid led to a concentration-dependent increase in the GABA release.
Localization (release) of GABA in cerebrospinal fluid associated with gaba
17) Confidence 0.70 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8510767 Disease Relevance 0.31 Pain Relevance 0.55
Hypothalamic superfusion with the neutrotoxin tetrodotoxin (1 mumol/l) led to a long-lasting decrease in the GABA release.
Localization (release) of GABA associated with tetrodotoxin and gaba
18) Confidence 0.70 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8510767 Disease Relevance 0.39 Pain Relevance 0.65
The role of specific dopamine receptor subtypes in the regulation of GABA release in the substantia nigra was investigated using microdialysis in the awake rat.
Localization (release) of GABA in substantia nigra associated with gaba, substantia nigra and dopamine receptor
19) Confidence 0.70 Published 1999 Journal Synapse Section Abstract Doc Link 10188635 Disease Relevance 0 Pain Relevance 0.78
Perfusion with the lower (10 microM) N-methyl-D-aspartate concentration in the dorsolateral striatum did not affect striatal dopamine, glutamate and GABA release or nigral GABA release.
Localization (release) of GABA in striatum associated with gaba, glutamate and dopamine
20) Confidence 0.70 Published 1996 Journal Neuroscience Section Abstract Doc Link 8730708 Disease Relevance 0 Pain Relevance 0.96

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