INT343910

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.30
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TLR4, Icam1) extracellular space (Icam1) signal transduction (TLR4)
cell adhesion (Icam1) intracellular (TLR4) cytoplasm (TLR4)
Anatomy Link Frequency
hepatocytes 2
TLR4 (Homo sapiens)
Icam1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 47 98.78 Very High Very High Very High
ischemia 4 78.32 Quite High
Inflammation 66 74.36 Quite High
Inflammatory response 15 41.00 Quite Low
Bile 5 33.88 Quite Low
agonist 54 28.32 Quite Low
alcohol 4 25.36 Quite Low
fibrosis 18 5.00 Very Low Very Low Very Low
chemokine 10 5.00 Very Low Very Low Very Low
tolerance 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 31 98.24 Very High Very High Very High
Reperfusion Injury 11 97.76 Very High Very High Very High
Cv Unclassified Under Development 3 78.32 Quite High
INFLAMMATION 80 74.36 Quite High
Myocardial Infarction 1 60.44 Quite High
Hemorrhagic Shock 1 58.52 Quite High
Organ Transplantation 1 57.76 Quite High
Primary Sclerosing Cholangitis 1 43.56 Quite Low
Biliary Liver Cirrhosis 4 41.28 Quite Low
Hepatitis 5 35.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analysis of TLR4 chimeric mice with hepatic IRI indicates that mutation of TLR4 within either BM-derived or non-BM-derived TLR4 reduces hepatic IRI in the late reperfusion stage via reduced cytokine release and neutrophil infiltration, whereas non-BM-derived TLR4 regulates the expression of ICAM-1 on hepatocytes and LSECs, exacerbating the injury [108].
TLR4 Regulation (regulates) of Gene_expression (expression) of ICAM-1 in hepatocytes associated with reperfusion injury, injury and cytokine
1) Confidence 0.04 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 1.30 Pain Relevance 0.22

General Comments

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