INT343911

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.41
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Mthfd1, IL12A) extracellular space (IL12A) mitochondrion (Mthfd1)
extracellular region (IL12A) oxidoreductase activity (Mthfd1) ligase activity (Mthfd1)
Anatomy Link Frequency
T cell 2
Mthfd1 (Mus musculus)
IL12A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 47 97.00 Very High Very High Very High
agonist 54 86.92 High High
tolerance 7 54.32 Quite High
Inflammation 66 47.28 Quite Low
chemokine 10 11.60 Low Low
fibrosis 18 5.00 Very Low Very Low Very Low
Inflammatory response 15 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 1 99.20 Very High Very High Very High
Infection 12 86.52 High High
Hepatitis C Virus Infection 10 75.36 Quite High
Injury 31 50.00 Quite Low
Stress 9 48.64 Quite Low
INFLAMMATION 80 47.28 Quite Low
Cirrhosis 61 5.00 Very Low Very Low Very Low
Fibrosis 24 5.00 Very Low Very Low Very Low
Apoptosis 13 5.00 Very Low Very Low Very Low
Reperfusion Injury 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a mouse model of diabetes, HMGB1 upregulates CD40 expression and enhances IL-12 production by DCs, leading to natural killer (NK)T cell activation and subsequent NKT cell-dependent augmentation of IFN-?
DCs Positive_regulation (enhances) of Gene_expression (production) of IL-12 in T cell associated with diabetes mellitus
1) Confidence 0.00 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.41 Pain Relevance 0.23

General Comments

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