INT343915

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.19
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Traf1, TICAM1) cytosol (TICAM1) plasma membrane (TICAM1)
signal transducer activity (TICAM1) cytoplasm (Traf1)
Anatomy Link Frequency
A20 1
Traf1 (Mus musculus)
TICAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 47 84.84 Quite High
Inflammatory response 15 76.80 Quite High
Inflammation 66 59.92 Quite High
agonist 54 5.00 Very Low Very Low Very Low
fibrosis 18 5.00 Very Low Very Low Very Low
chemokine 10 5.00 Very Low Very Low Very Low
tolerance 7 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 80 76.80 Quite High
Injury 31 50.00 Quite Low
Cirrhosis 61 46.52 Quite Low
Apoptosis 13 39.32 Quite Low
Adhesions 7 26.76 Quite Low
Cryptosporidiosis 1 18.16 Low Low
Infection 12 16.32 Low Low
Viral Infection 2 6.96 Low Low
Fibrosis 24 5.00 Very Low Very Low Very Low
Reperfusion Injury 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other intracellular negative regulatory proteins act further downstream in the signaling pathway, and include IRAK-M (IRAK family member but lacks kinase activity), IRAK-2c and MyD88s (splicing variants of IRAK and MyD88), TRAF1 and TRAF4 (TRAF family members that interact with TRIF activity), A20 (a de-ubiquitinating enzyme that can remove ubiquitin moieties from TRAF6) [33], and syntenin [34].
TRAF Binding (interact) of TRIF in A20
1) Confidence 0.08 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.19 Pain Relevance 0.17

General Comments

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