INT343916

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Context Info
Confidence 0.16
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.17
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Hspa1a) intracellular (TNF) extracellular matrix organization (TNF)
response to stress (Hspa1a) cytoplasm (Hspa1a) extracellular space (TNF)
Anatomy Link Frequency
hepatocytes 2
Hspa1a (Mus musculus)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 4 100.00 Very High Very High Very High
agonist 54 92.56 High High
Bile 5 91.80 High High
Inflammatory mediators 3 56.64 Quite High
cytokine 47 54.00 Quite High
Inflammation 66 49.36 Quite Low
tolerance 7 41.20 Quite Low
Inflammatory response 15 38.88 Quite Low
chemokine 10 18.24 Low Low
fibrosis 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reperfusion Injury 11 100.00 Very High Very High Very High
Stress 9 100.00 Very High Very High Very High
Cv Unclassified Under Development 3 100.00 Very High Very High Very High
Targeted Disruption 1 94.32 High High
Hepatitis 5 90.24 High High
Hepatitis C Virus Infection 10 88.72 High High
Alzheimer's Dementia 2 78.24 Quite High
Infection 12 76.32 Quite High
Adhesions 7 73.40 Quite High
Acute-phase Reaction 1 68.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endogenous TLR4 ligands such as extracellular HSP72, a strongly stress-inducible 72-kDa protein that is released during ischemia-reperfusion injury (IRI), can stimulate hepatocytes to produce MIP-2, IL-6 and TNF-?
HSP72 Positive_regulation (stimulate) of Gene_expression (produce) of TNF in hepatocytes associated with stress, reperfusion injury and ischemia
1) Confidence 0.16 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 1.17 Pain Relevance 0.41

General Comments

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