INT343916

Context Info Confidence 0.16 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.17 Pain Relevance 0.41

mitochondrion (Hspa1a) intracellular (TNF) extracellular matrix organization (TNF) response to stress (Hspa1a) cytoplasm (Hspa1a) extracellular space (TNF)

Anatomy Link Frequency hepatocytes 2 Hspa1a (Mus musculus) TNF (Homo sapiens)

Pain Link Frequency Relevance Heat ischemia 4 100.00 agonist 54 92.56 Bile 5 91.80 Inflammatory mediators 3 56.64 cytokine 47 54.00 Inflammation 66 49.36 tolerance 7 41.20 Inflammatory response 15 38.88 chemokine 10 18.24 fibrosis 18 5.00

Disease Link Frequency Relevance Heat Reperfusion Injury 11 100.00 Stress 9 100.00 Cv Unclassified Under Development 3 100.00 Targeted Disruption 1 94.32 Hepatitis 5 90.24 Hepatitis C Virus Infection 10 88.72 Alzheimer's Dementia 2 78.24 Infection 12 76.32 Adhesions 7 73.40 Acute-phase Reaction 1 68.12

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Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Endogenous TLR4 ligands such as extracellular HSP72, a strongly stress-inducible 72-kDa protein that is released during ischemia-reperfusion injury (IRI), can stimulate hepatocytes to produce MIP-2, IL-6 and TNF-?

HSP72 Positive_regulation (stimulate) of Gene_expression (produce) of TNF in hepatocytes associated with stress, reperfusion injury and ischemia

1) Confidence 0.16 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 1.17 Pain Relevance 0.41

General Comments

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