INT343920

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.97
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (TLR4, Hmgb1) cell morphogenesis (Hmgb1) intracellular (TLR4)
DNA binding (Hmgb1) signal transduction (TLR4) extracellular space (Hmgb1)
TLR4 (Homo sapiens)
Hmgb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 66 89.32 High High
Inflammatory response 15 42.24 Quite Low
cytokine 47 12.88 Low Low
agonist 54 5.00 Very Low Very Low Very Low
fibrosis 18 5.00 Very Low Very Low Very Low
chemokine 10 5.00 Very Low Very Low Very Low
tolerance 7 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 2 100.00 Very High Very High Very High
Cancer 3 95.32 Very High Very High Very High
Vesicular Stomatitis 1 94.12 High High
Respiratory Syncytial Virus 1 93.24 High High
Communicable Diseases 2 90.68 High High
INFLAMMATION 80 89.32 High High
Injury 31 85.60 High High
Infection 12 71.96 Quite High
Cryptosporidiosis 1 71.56 Quite High
Cirrhosis 61 21.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Besides its natural exogenous substrate LPS, there are endogenous substrates for TLR4 that also bind and activate TLR4 [43], including low molecular weight hyaluronic acid [44,45], free fatty acids (FFAs) [46], fibrinogen [47], fibronectin [48], heat shock proteins (HSPs) 60 and 70 [49,50] and high mobility group box (HMGB)1 [51].
TLR4 Binding (bind) of HMGB associated with shock
1) Confidence 0.39 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.97 Pain Relevance 0.13

General Comments

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