INT343942

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 5.79
Pain Relevance 9.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hgs) endosome (Hgs) cytoplasm (Hgs)
Anatomy Link Frequency
spinal cord 6
sciatic nerve 1
Hgs (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 252 100.00 Very High Very High Very High
Sciatic nerve 207 99.84 Very High Very High Very High
Eae 189 99.72 Very High Very High Very High
c fibre 378 99.40 Very High Very High Very High
qutenza 117 99.26 Very High Very High Very High
lidocaine 153 99.20 Very High Very High Very High
Central nervous system 252 97.32 Very High Very High Very High
Peripheral nerve injury 234 95.20 Very High Very High Very High
spinal dorsal horn 18 88.20 High High
Action potential 63 88.12 High High
Disease Link Frequency Relevance Heat
Injury 360 99.72 Very High Very High Very High
Nervous System Injury 531 99.40 Very High Very High Very High
Cardiovascular Disease 68 97.68 Very High Very High Very High
Coronary Artery Disease 50 97.32 Very High Very High Very High
Stroke 50 95.72 Very High Very High Very High
Disorder Of Lipid Metabolism 74 94.40 High High
Myocardial Infarction 6 83.48 Quite High
Hypersensitivity 72 78.48 Quite High
Pain 72 77.80 Quite High
Increased Venous Pressure Under Development 24 75.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significantly elevated HRs were found in women in the fifth quintile for all cause, CVD, and IHD deaths (P for trend <0.001) and for stroke (P for trend 0.03).
Positive_regulation (elevated) of HRs associated with coronary artery disease, stroke and cardiovascular disease
1) Confidence 0.42 Published 2010 Journal Eur J Epidemiol Section Body Doc Link PMC2991549 Disease Relevance 1.43 Pain Relevance 0
For example for all cause deaths in women the age-adjusted HRs per1 mmol/l increase in triglycerides were 1.27 and 1.26 in ours and the Danish study, respectively.
Positive_regulation (increase) of HRs
2) Confidence 0.28 Published 2010 Journal Eur J Epidemiol Section Body Doc Link PMC2991549 Disease Relevance 1.10 Pain Relevance 0
Electrical stimulation at C-fiber intensities also produced an increase in HRP in the ipsilateral dorsal spinal cord 24 hrs after the stimulation (Figure 3B).
Positive_regulation (increase) of hrs in spinal cord associated with c fibre and spinal cord
3) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC2984489 Disease Relevance 0.27 Pain Relevance 1.10
In investigating the effects of electrical C-fiber stimulation we examined the contralateral as well as the ipsilateral lumbar dorsal spinal cord and found that the increase in Evans Blue accumulation 24 hrs after stimulation was produced in the contralateral, as well as the ipsilateral dorsal spinal cord (Figure 5A).
Positive_regulation (increase) of hrs in spinal cord associated with c fibre and spinal cord
4) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC2984489 Disease Relevance 0.09 Pain Relevance 1.37
We found that there was a significant increase in Evans Blue accumulation in the dorsal spinal cord 24 hrs after the second nerve injury (Figure 2B).
Positive_regulation (increase) of hrs in spinal cord associated with nervous system injury and spinal cord
5) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC2984489 Disease Relevance 0.89 Pain Relevance 0.71
By contrast, stimulation sufficient to recruit primary afferent C-fibers (10 mA; 10 Hz; 5 min) caused a delayed increase in Evans Blue accumulation: Evans Blue was not different from control 3 hrs after C-fiber stimulation (not illustrated), but was significantly increased 24 hrs after stimulation (Figure 3A).
Neg (not) Positive_regulation (increased) of hrs associated with c fibre
6) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC2984489 Disease Relevance 0.29 Pain Relevance 1.00
Capsaicin applied to the sciatic nerve causes increased BSCB permeability at 24 hrs
Positive_regulation (increased) of hrs in sciatic nerve associated with qutenza and sciatic nerve
7) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC2984489 Disease Relevance 0 Pain Relevance 1.38
In investigating the effects of electrical C-fiber stimulation we examined the contralateral as well as the ipsilateral lumbar dorsal spinal cord and found that the increase in Evans Blue accumulation 24 hrs after stimulation was produced in the contralateral, as well as the ipsilateral dorsal spinal cord (Figure 5A).
Positive_regulation (increase) of hrs in spinal cord associated with c fibre and spinal cord
8) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC2984489 Disease Relevance 0.09 Pain Relevance 1.37
We found that Evans Blue accumulation was significantly increased throughout the spinal cord 24 hrs after CCI and SNI (Figure 5B).
Positive_regulation (increased) of hrs in spinal cord associated with nervous system injury, eae and spinal cord
9) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC2984489 Disease Relevance 0.75 Pain Relevance 1.06
We found that there was a significant increase in Evans Blue accumulation in the dorsal spinal cord 24 hrs after the second nerve injury (Figure 2B).
Positive_regulation (accumulation) of hrs in spinal cord associated with nervous system injury and spinal cord
10) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC2984489 Disease Relevance 0.88 Pain Relevance 0.71
We found that applying lidocaine prior to the stimulation prevented the increase in Evans Blue accumulation 24 hrs later (Figure 3C).
Positive_regulation (increase) of hrs associated with lidocaine
11) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC2984489 Disease Relevance 0 Pain Relevance 1.21

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