INT343950

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.63
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SERPINE2) cytosol (SERPINE2) extracellular space (SERPINE2)
extracellular region (SERPINE2) plasma membrane (Slco1c1)
Anatomy Link Frequency
spinal cord 1
SERPINE2 (Homo sapiens)
Slco1c1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Peripheral nerve injury 26 100.00 Very High Very High Very High
Stimulus evoked pain 7 98.68 Very High Very High Very High
Dorsal horn 16 97.12 Very High Very High Very High
metalloproteinase 3 96.36 Very High Very High Very High
Spinal cord 28 95.08 Very High Very High Very High
medulla 1 63.08 Quite High
c fibre 42 50.00 Quite Low
Central nervous system 28 39.48 Quite Low
lidocaine 17 12.16 Low Low
Sciatic nerve 23 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nervous System Injury 59 100.00 Very High Very High Very High
Hypersensitivity 8 98.68 Very High Very High Very High
Pain 8 98.00 Very High Very High Very High
Injury 40 5.00 Very Low Very Low Very Low
Neurogenic Inflammation 3 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 2 5.00 Very Low Very Low Very Low
Stroke 2 5.00 Very Low Very Low Very Low
Demyelinating Disease 1 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low
Edema 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the PNI-induced increase in BBB permeability is not sufficient on its own to cause pain hypersensitivity because permeability is increased throughout the spinal cord whereas pain hypersensitivity is typically restricted to the region near the nerve injury.
PNI Positive_regulation (increase) of BBB in spinal cord associated with nervous system injury, hypersensitivity, stimulus evoked pain, spinal cord and peripheral nerve injury
1) Confidence 0.00 Published 2010 Journal Mol Pain Section Body Doc Link PMC2984489 Disease Relevance 1.63 Pain Relevance 1.07

General Comments

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