INT343999

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

protein complex (INCENP, BMP2) cytoplasm (INCENP, BMP2) chromosome segregation (INCENP) embryo development (BMP2) cell-cell signaling (BMP2) cytosol (INCENP)

Anatomy Link Frequency platelet 1 INCENP (Homo sapiens) BMP2 (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 2 30.56 imagery 5 15.60 cytokine 1 5.00 anesthesia 1 5.00 withdrawal 1 5.00 Inflammation 1 5.00 Buprenorphine 1 5.00 isoflurane 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Stress 4 32.84 Fracture Healing 1 30.88 Osteoporosis 2 5.00 Injury 2 5.00 Pain 1 5.00 Hyperplasia 1 5.00 Toxicity 1 5.00 Dislocations 1 5.00 Wound Healing 1 5.00 INFLAMMATION 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Activated platelet supernatants were previously reported to hold a potent mitogenic and chemotactic activity for mesenchymal progenitor cells, however, to decrease osteogenic differentiation.26 ECs, in contrast, enhance the osteogenic potential of bone marrow stromal cells (BMSCs) grown in co-culture in vitro, likely via BMP-2 production.27 In this study, increased angiogenecity of the PRP significantly enhanced the late stage osteogenic differentiation of hBMSCs co-cultured with hCBOECs.

in vitro Positive_regulation (increased) of BMP-2 in platelet

1) Confidence 0.01 Published 2010 Journal The Journal of Advanced Prosthodontics Section Body Doc Link PMC2984511 Disease Relevance 0 Pain Relevance 0

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