INT34402

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Context Info
Confidence 0.39
First Reported 1980
Last Reported 1988
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.66
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Tshb) cellular_component (Tshb)
Anatomy Link Frequency
thyroid 6
brain 2
Tshb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 12 100.00 Very High Very High Very High
Morphine 9 100.00 Very High Very High Very High
methadone 5 99.98 Very High Very High Very High
Endogenous opioid 3 99.84 Very High Very High Very High
tolerance 1 99.72 Very High Very High Very High
antagonist 1 97.72 Very High Very High Very High
withdrawal 1 95.60 Very High Very High Very High
Opioid 2 94.32 High High
opiate 2 93.88 High High
Central nervous system 1 89.80 High High
Disease Link Frequency Relevance Heat
Uremia 10 99.84 Very High Very High Very High
Weight Loss 1 90.88 High High
Appetite Loss 1 88.16 High High
Renal Failure 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of morphine on the release of thyroid-stimulating hormone stimulated by exposure to cold, thyroidectomy and the administration of thyrotrophin releasing hormone in male rats.
Regulation (Effect) of Localization (release) of thyroid-stimulating hormone in thyroid associated with narcan and morphine
1) Confidence 0.39 Published 1980 Journal J. Endocrinol. Section Title Doc Link 6776217 Disease Relevance 0 Pain Relevance 0.64
The role of endogenous opioids in the control of thyroid-stimulating hormone (TSH) secretion in uremic male rats was investigated using the narcotic antagonist naloxone.
Regulation (control) of Localization (secretion) of thyroid-stimulating hormone in thyroid associated with antagonist, narcan, endogenous opioid and uremia
2) Confidence 0.34 Published 1988 Journal Neuroendocrinology Section Abstract Doc Link 3362301 Disease Relevance 0.66 Pain Relevance 0.33
In addition, marked tolerance to methadone effects on GH, CS, thyroid-stimulating hormone (TSH) and prolactin (PRL) secretion developed during chronic postnatal administration, and effects on PRL and TSH secretion persisted after drug withdrawal.
Regulation (effects) of Localization (secretion) of thyroid-stimulating hormone in thyroid associated with tolerance, methadone and withdrawal
3) Confidence 0.30 Published 1984 Journal Dev Pharmacol Ther Section Abstract Doc Link 6518945 Disease Relevance 0 Pain Relevance 0.54
To test this hypothesis we examined the effects of the systemic administration of N-methylmorphine chloride, a quaternary analogue of morphine that does not cross the blood-brain barrier, on the release of corticosterone, growth hormone, prolactin, luteinizing hormone, and thyroid stimulating hormone in the rat.
Spec (examined) Regulation (effects) of Localization (release) of thyroid stimulating hormone in brain associated with morphine
4) Confidence 0.23 Published 1987 Journal Psychoneuroendocrinology Section Abstract Doc Link 3035598 Disease Relevance 0 Pain Relevance 0.57

General Comments

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