INT344059

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.54
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Esl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Gabapentin 9 96.58 Very High Very High Very High
carbamazepine 36 96.14 Very High Very High Very High
antiepileptic Drug 57 68.24 Quite High
Lamotrigine 15 67.68 Quite High
headache 15 62.16 Quite High
sodium channel 33 59.68 Quite High
anticonvulsant 6 26.08 Quite Low
Neuropathic pain 3 5.00 Very Low Very Low Very Low
amygdala 3 5.00 Very Low Very Low Very Low
gABA 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Partial Seizures 42 96.20 Very High Very High Very High
Body Weight 6 94.72 High High
Dyslipidemia /

Combined Dyslipidemia

3 93.32 High High
Hyponatremia 6 92.68 High High
Exanthema 6 85.68 High High
Epilepsy 72 78.72 Quite High
Convulsion 105 73.92 Quite High
Toxicity 3 73.88 Quite High
Fatigue 9 68.72 Quite High
Vertigo 6 67.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ESL may not cause QT prolongation, but the evaluation of electrocardiogram recordings during clinical trials showed an increase in PR interval in ESL-treated patients, which was highest in the 1200 mg dose group compared with the placebo group.
Positive_regulation (increase) of ESL
1) Confidence 0.04 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2987506 Disease Relevance 0.54 Pain Relevance 0.12
From a pediatrician’s point of view, the lack of an influence of ESL on the clearance of sodium valproate, topiramate, phenobarbital, carbamazepine, clobazam, gabapentin, and levetiracetam, as well as no evidence of QT prolongation, is of importance (although the evaluation of electrocardiogram recordings during clinical trials showed an increase in PR interval in ESL-treated adults, which was highest in the 1200 mg dose group when compared with placebo).29

Drug interactions

Positive_regulation (increase) of ESL associated with gabapentin and carbamazepine
2) Confidence 0.04 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2987506 Disease Relevance 0.14 Pain Relevance 0.17
The convenience of once-daily dosing and a short/simple titration regimen, in combination with a favorable efficacy and safety profile, might promote ESL as a valid alternative to the current adjunctive AED therapy armamentarium for drug-resistant partial seizures.
Spec (might) Positive_regulation (promote) of ESL associated with partial seizures
3) Confidence 0.04 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2987506 Disease Relevance 0.77 Pain Relevance 0.19

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox