INT344061

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.90
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 1
Esl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Lamotrigine 20 99.60 Very High Very High Very High
carbamazepine 48 99.30 Very High Very High Very High
sodium channel 44 97.12 Very High Very High Very High
Gabapentin 12 96.36 Very High Very High Very High
antiepileptic Drug 76 92.84 High High
headache 20 44.32 Quite Low
anticonvulsant 8 5.00 Very Low Very Low Very Low
Neuropathic pain 4 5.00 Very Low Very Low Very Low
amygdala 4 5.00 Very Low Very Low Very Low
gABA 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 140 97.98 Very High Very High Very High
Partial Seizures 56 87.04 High High
Epilepsy 96 83.40 Quite High
Toxicity 4 56.04 Quite High
Fatigue 12 50.88 Quite High
Vertigo 8 49.68 Quite Low
Vomiting 28 45.48 Quite Low
Headache 20 44.32 Quite Low
Diplopia 16 43.16 Quite Low
Dizziness 20 39.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The placebo-controlled and open-label studies of ESL performed to date are summarized in Table 1.
Regulation (controlled) of ESL
1) Confidence 0.04 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2987506 Disease Relevance 0.22 Pain Relevance 0.27
As a consequence, ESL clearance (and clearance of other metabolites) is affected by renal function, whereas glucuronidation and/or formation of R-licarbazepine or oxcarbazepine seem to be unaffected by liver impairment.34 As seen in previous studies of other AEDs, clearance in children is higher than in adults.
Regulation (affected) of ESL in liver associated with antiepileptic drug
2) Confidence 0.02 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2987506 Disease Relevance 0.11 Pain Relevance 0.05
From a pediatrician’s point of view, the lack of an influence of ESL on the clearance of sodium valproate, topiramate, phenobarbital, carbamazepine, clobazam, gabapentin, and levetiracetam, as well as no evidence of QT prolongation, is of importance (although the evaluation of electrocardiogram recordings during clinical trials showed an increase in PR interval in ESL-treated adults, which was highest in the 1200 mg dose group when compared with placebo).29

Drug interactions

Regulation (influence) of ESL associated with gabapentin and carbamazepine
3) Confidence 0.02 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2987506 Disease Relevance 0.16 Pain Relevance 0.18
The results of previous Phase II and III studies have demonstrated and confirmed the efficacy and tolerability of ESL 800 mg and 1200 mg once daily as add-on therapy for patients with drug-resistant partial-onset seizures.16,24,30,31 Interestingly, in patients treated with carbamazepine or lamotrigine, no differences in ESL efficacy were observed when compared with patients not treated with concomitant VGSC blockers.
Regulation (efficacy) of ESL associated with convulsion, sodium channel, lamotrigine and carbamazepine
4) Confidence 0.02 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2987506 Disease Relevance 0.41 Pain Relevance 0.33

General Comments

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