INT344064

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.25
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 2
Esl1 (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 22 94.80 High High
anticonvulsant 4 89.04 High High
antiepileptic Drug 38 87.28 High High
Lamotrigine 10 70.64 Quite High
Gabapentin 6 61.08 Quite High
carbamazepine 24 60.20 Quite High
headache 10 50.56 Quite High
Neuropathic pain 2 5.00 Very Low Very Low Very Low
amygdala 2 5.00 Very Low Very Low Very Low
gABA 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Partial Seizures 28 99.92 Very High Very High Very High
Convulsion 70 91.64 High High
Epilepsy 48 90.68 High High
Dizziness 10 53.84 Quite High
Vomiting 14 52.00 Quite High
Diplopia 8 51.36 Quite High
Headache 10 50.56 Quite High
Vertigo 4 47.68 Quite Low
Fatigue 6 46.64 Quite Low
Body Weight 4 30.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ESL is a prodrug of eslicarbazepine (the active entity responsible for pharmacologic effects), and is rapidly and extensively hydrolyzed during first pass by liver esterases after oral administration.
Localization (hydrolyzed) of ESL in liver
1) Confidence 0.06 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Abstract Doc Link PMC2987506 Disease Relevance 1.25 Pain Relevance 0.18
The activity of CYP1A2, CYP2A6, CYP2B6, CYP2D6, CYP2E1, CYP3A4, and CYP2C9 was not affected, and only a moderate inhibitory effect on CYP2C19 (by 38%), as well as a moderate increment of UDP-glucuronosyl-transferase 1A1-mediated ethinylestradiol glucuronidation (by 39%), was seen in the presence of ESL in human liver microsomes in vitro.36

In vivo studies

Localization (presence) of ESL in liver
2) Confidence 0.06 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2987506 Disease Relevance 0 Pain Relevance 0.17

General Comments

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