INT3441

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Context Info
Confidence 0.38
First Reported 1978
Last Reported 2010
Negated 39
Speculated 5
Reported most in Abstract
Documents 117
Total Number 122
Disease Relevance 8.67
Pain Relevance 87.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Abat)
Anatomy Link Frequency
neurons 16
striatum 13
hippocampus 11
substantia nigra 10
brain 8
Abat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 1313 100.00 Very High Very High Very High
Glutamate 551 100.00 Very High Very High Very High
antagonist 334 100.00 Very High Very High Very High
adenocard 227 100.00 Very High Very High Very High
Neurotransmitter 212 100.00 Very High Very High Very High
Dopamine 180 100.00 Very High Very High Very High
tetrodotoxin 111 100.00 Very High Very High Very High
Morphine 80 100.00 Very High Very High Very High
Substantia nigra 71 100.00 Very High Very High Very High
Serotonin 69 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 135 100.00 Very High Very High Very High
Temporomandibular Joint Syndrome 11 99.84 Very High Very High Very High
Urological Neuroanatomy 39 99.68 Very High Very High Very High
Cv Unclassified Under Development 12 99.68 Very High Very High Very High
Hypoxia 29 99.52 Very High Very High Very High
Pain 68 99.48 Very High Very High Very High
Epilepsy 117 98.40 Very High Very High Very High
Nociception 32 95.88 Very High Very High Very High
Depression 26 94.28 High High
Cold Sores 2 89.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of clonidine on the release of endogenous gamma-aminobutyric acid (GABA) have been studied in superfused synaptosomes prepared from rat hypothalamus, nucleus tractus solitarii (NTS) and cerebellum.
Regulation (effects) of Localization (release) of GABA in cerebellum associated with gaba and clonidine
1) Confidence 0.38 Published 1991 Journal Pharmacol. Res. Section Abstract Doc Link 1749748 Disease Relevance 0 Pain Relevance 0.60
In this latter case, the secretion of GABA in the perineuronal environment was dependent on neuronal excitation and occurred with the increase in extracellular potassium concentrations.


Regulation (dependent) of Localization (secretion) of GABA in neuronal associated with gaba
2) Confidence 0.31 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734545 Disease Relevance 0.46 Pain Relevance 0.74
The value for GABA release is probably not valid since it fell outside of the linear part of the regression line which was used for calculation.
Regulation (value) of Localization (release) of GABA associated with gaba
3) Confidence 0.27 Published 1981 Journal Anesthesiology Section Abstract Doc Link 7247056 Disease Relevance 0 Pain Relevance 0.89
The role of specific dopamine receptor subtypes in the regulation of GABA release in the substantia nigra was investigated using microdialysis in the awake rat.
Regulation (role) of Localization (release) of GABA in substantia nigra associated with gaba, substantia nigra and dopamine receptor
4) Confidence 0.27 Published 1999 Journal Synapse Section Abstract Doc Link 10188635 Disease Relevance 0 Pain Relevance 0.78
The role of specific dopamine receptor subtypes in the regulation of GABA release in the substantia nigra was investigated using microdialysis in the awake rat.
Regulation (regulation) of Localization (release) of GABA in substantia nigra associated with gaba, substantia nigra and dopamine receptor
5) Confidence 0.27 Published 1999 Journal Synapse Section Abstract Doc Link 10188635 Disease Relevance 0 Pain Relevance 0.78
Perfusion with the lower (10 microM) N-methyl-D-aspartate concentration in the dorsolateral striatum did not affect striatal dopamine, glutamate and GABA release or nigral GABA release.
Neg (not) Regulation (affect) of Localization (release) of GABA in striatum associated with gaba, glutamate and dopamine
6) Confidence 0.27 Published 1996 Journal Neuroscience Section Abstract Doc Link 8730708 Disease Relevance 0 Pain Relevance 0.97
These results indicate that the facilitatory response by alpha-GPC on GABA release does not depend on a direct activation of either muscarinic or nicotinic receptors, but suggest the involvement of the noradrenergic system.
Neg (not) Regulation (depend) of Localization (release) of GABA associated with gaba
7) Confidence 0.25 Published 1996 Journal Neurochem. Res. Section Abstract Doc Link 8726961 Disease Relevance 0 Pain Relevance 0.42
Evidence for an in vivo and in vitro modulation of endogenous cortical GABA release by alpha-glycerylphosphorylcholine.
Regulation (modulation) of Localization (release) of GABA associated with gaba
8) Confidence 0.25 Published 1996 Journal Neurochem. Res. Section Title Doc Link 8726961 Disease Relevance 0 Pain Relevance 0.41
In conclusion: 1) clonidine stimulates the release of GABA in rat cerebral cortex synaptosomes; 2) the effect is likely to occur by activation of alpha-1 and alpha-2 adrenoceptors possibly situated on GABAergic nerve endings; and 3) a differential distribution of alpha-1 and alpha-2 adrenoceptors regulating GABA release exists within the cortical subregions.
Regulation (regulating) of Localization (release) of GABA in nerve associated with gaba, gabaergic, cerebral cortex and clonidine
9) Confidence 0.25 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2835479 Disease Relevance 0.08 Pain Relevance 1.00
In other studies we have shown that gabapentin, pregabalin (Cunningham et al., 2004) and felbamate (Yang et al., 2007) also decrease glutamate release, albeit by different mechanisms, but have little effect on GABA release (Jones, unpublished observations; current paper).
Neg (little) Regulation (effect) of Localization (release) of GABA associated with pregabalin, gaba, glutamate and gabapentin
10) Confidence 0.25 Published 2010 Journal Neuroscience Section Body Doc Link PMC2877872 Disease Relevance 0.05 Pain Relevance 0.84
Phenytoin and lamotrigine both elicited a presynaptic modulation of glutamate and GABA release, decreasing the former, but concurrently increasing the latter (Cunningham et al., 2000; Cunningham and Jones, 2000).
Regulation (modulation) of Localization (release) of GABA associated with gaba, glutamate and lamotrigine
11) Confidence 0.25 Published 2010 Journal Neuroscience Section Body Doc Link PMC2877872 Disease Relevance 0.08 Pain Relevance 0.66
Whatever the mechanisms involved, tiagabine clearly had complex effects on different parameters of both spontaneous glutamate and GABA release.
Regulation (effects) of Localization (release) of GABA associated with gaba and glutamate
12) Confidence 0.25 Published 2010 Journal Neuroscience Section Body Doc Link PMC2877872 Disease Relevance 0 Pain Relevance 0.37
Regional specific effects of clozapine and haloperidol on GABA and dopamine release in rat basal ganglia.
Regulation (effects) of in basal ganglia Localization (release) of GABA in ventral associated with dopamine and gaba
13) Confidence 0.24 Published 1990 Journal Eur. J. Pharmacol. Section Title Doc Link 2073921 Disease Relevance 0 Pain Relevance 0.75
Thus, haloperidol and clozapine are clearly distinguished by their effects on GABA release in the fundus striati and globus pallidus (both drugs increased GABA release in the dorsolateral striatum).
Regulation (effects) of Localization (release) of GABA in fundus associated with gaba
14) Confidence 0.24 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2073921 Disease Relevance 0 Pain Relevance 0.82
Regional specific effects of clozapine and haloperidol on GABA and dopamine release in rat basal ganglia.
Regulation (effects) of Localization (release) of GABA in basal ganglia associated with dopamine and gaba
15) Confidence 0.24 Published 1990 Journal Eur. J. Pharmacol. Section Title Doc Link 2073921 Disease Relevance 0 Pain Relevance 0.73
Thus, haloperidol and clozapine are clearly distinguished by their effects on GABA release in the fundus striati and globus pallidus (both drugs increased GABA release in the dorsolateral striatum).
Regulation (effects) of in fundus Localization (release) of GABA in striatum associated with gaba
16) Confidence 0.24 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2073921 Disease Relevance 0 Pain Relevance 0.85
These data suggest that (1) regional differences in the effects of haloperidol and clozapine on GABA release in the basal ganglia may parallel the unique clinical profiles of these drugs; and (2) increases in dopamine release may occur independently of a GABAergic component in the dorsolateral striatum following low doses of haloperidol and clozapine and in the fundus striati following all effective doses of haloperidol.
Regulation (effects) of Localization (release) of GABA in basal ganglia associated with dopamine, gaba and gabaergic
17) Confidence 0.24 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2073921 Disease Relevance 0 Pain Relevance 0.93
Effects of recurrent withdrawal on spinal GABA release during chronic morphine infusion in the rat.
Regulation (Effects) of Localization (release) of GABA in spinal associated with gaba, narcan, withdrawal and morphine
18) Confidence 0.24 Published 2006 Journal Eur. J. Pharmacol. Section Title Doc Link 16540107 Disease Relevance 0.19 Pain Relevance 1.19
Effect of L-glutamic acid on [14C]GABA release from isolated rat retina.
Regulation (Effect) of Localization (release) of GABA in retina associated with gaba
19) Confidence 0.24 Published 1981 Journal Brain Res. Section Title Doc Link 6118201 Disease Relevance 0 Pain Relevance 0.40
Acetylcholine, norepinephrine, dopamine, glycine and taurine did not have any significant effects on GABA release.
Neg (not) Regulation (effects) of Localization (release) of GABA associated with gaba and dopamine
20) Confidence 0.24 Published 1981 Journal Brain Res. Section Abstract Doc Link 6118201 Disease Relevance 0 Pain Relevance 0.40

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