INT34413

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Context Info
Confidence 0.12
First Reported 1987
Last Reported 1993
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.24
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
PGE2 1
Pia1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 18 100.00 Very High Very High Very High
Clonidine 13 100.00 Very High Very High Very High
agonist 6 84.64 Quite High
Hippocampus 3 80.08 Quite High
noradrenaline 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 3 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Preincubation of OMCD samples with pertussis toxin (100 ng/ml or 1 micrograms/ml) relieved the inhibitory effects of CLO and PIA but did not affect the action of PGE2.
Negative_regulation (effects) of PIA in PGE2 associated with adenocard, bordatella infection and clonidine
1) Confidence 0.12 Published 1993 Journal Pflugers Arch. Section Abstract Doc Link 8102483 Disease Relevance 0.24 Pain Relevance 0.97
Forskolin had a small, but significant stimulatory effect on NA overflow, but did not reduce the prejunctional inhibitory effect of R-PIA.
Negative_regulation (effect) of R-PIA
2) Confidence 0.07 Published 1987 Journal Acta Physiol. Scand. Section Abstract Doc Link 3035877 Disease Relevance 0 Pain Relevance 0.40
Forskolin had a small, but significant stimulatory effect on NA overflow, but did not reduce the prejunctional inhibitory effect of R-PIA.
Neg (not) Negative_regulation (reduce) of R-PIA
3) Confidence 0.07 Published 1987 Journal Acta Physiol. Scand. Section Abstract Doc Link 3035877 Disease Relevance 0 Pain Relevance 0.40
The prejunctional inhibitory effect of R-PIA (1 microM) on NA release, stimulated by a 3 Hz stimulation, was abolished by NEM pretreatment, which also eliminated the dose-dependent prejunctional effect of clonidine and reduced the facilitatory effect of yohimbine.
Negative_regulation (effect) of R-PIA associated with clonidine
4) Confidence 0.07 Published 1987 Journal Acta Physiol. Scand. Section Abstract Doc Link 3035877 Disease Relevance 0 Pain Relevance 0.40

General Comments

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