INT3442

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Context Info
Confidence 0.42
First Reported 1978
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 4.36
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lcat) extracellular region (Lcat) transferase activity, transferring acyl groups (Lcat)
Anatomy Link Frequency
liver 1
Lcat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 60 74.96 Quite High
Angina 1 50.40 Quite High
fibrosis 8 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 297 99.06 Very High Very High Very High
Liver Disease 56 98.56 Very High Very High Very High
Cirrhosis 68 93.80 High High
Atherosclerosis 6 92.52 High High
Coronary Artery Disease 2 82.04 Quite High
INFLAMMATION 64 74.96 Quite High
Stress 40 58.80 Quite High
Targeted Disruption 12 58.60 Quite High
Hemolysis 1 53.80 Quite High
Angina 1 50.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An interesting finding was the presence of severe antheroma in a small number of patients with low normal level of serum cholesterol and high LCAT activity.
Negative_regulation (level) of LCAT
1) Confidence 0.42 Published 1978 Journal Scand. J. Clin. Lab. Invest. Suppl. Section Abstract Doc Link 746339 Disease Relevance 0.49 Pain Relevance 0.05
Although reduced LCAT activity is common in a variety of liver diseases [46], the current report is, to the best of our knowledge, the first to identify increased CETP and PLTP activities as being associated with chronic liver impairment.
Negative_regulation (reduced) of LCAT in liver associated with liver disease
2) Confidence 0.28 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.82 Pain Relevance 0
The combination of decreased LCAT and increased CETP activities in the patients probably resulted in the increase in small HDL particles.
Negative_regulation (decreased) of LCAT associated with disorder of lipid metabolism
3) Confidence 0.24 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.91 Pain Relevance 0
An increase in PLTP would lead to larger HDL particles, while an enhancement in CETP and a decrease in LCAT would result in smaller HDL particles with an increase in the HDL3 sub-fraction.
Negative_regulation (decrease) of LCAT associated with disorder of lipid metabolism
4) Confidence 0.24 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 1.05 Pain Relevance 0.04
We observed a significant increase in serum CETP and PLTP, and a decrease in LCAT activities in patients relative to controls (Table 2).


Negative_regulation (decrease) of LCAT
5) Confidence 0.20 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 1.10 Pain Relevance 0.03

General Comments

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