INT344308

Context Info Confidence 0.09 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.24 Pain Relevance 0.03

cell morphogenesis (PDPN) embryo development (PDPN) cytoplasm (VEGFA) cell proliferation (PDPN) signal transduction (PDPN) extracellular space (VEGFA)

PDPN (Homo sapiens) VEGFA (Homo sapiens)

Pain Link Frequency Relevance Heat Kinase C 1 60.64 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Cancer 82 90.56 Metastasis 25 85.44 Skin Cancer 17 41.32 Lung Cancer 1 23.40 Adenocarcinoma 1 22.24 Malignant Neoplastic Disease 14 15.68 Breast Cancer 1 5.16 Small Cell Lung Carcinoma 2 5.00 Germ Cell And Embryonal Neoplasms 1 5.00 Respiratory Failure 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Taken together, podoplanin-dependent downregulation of VEGF-C is mediated by the direct and/or indirect increase of active JNK level in LSCCs.

Positive_regulation (mediated) of podoplanin Negative_regulation (downregulation) of VEGF

1) Confidence 0.09 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.24 Pain Relevance 0.03

General Comments

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