INT344311

Context Info Confidence 0.09 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.81 Pain Relevance 0

cell morphogenesis (PDPN) embryo development (PDPN) cytoplasm (VEGFA) cell proliferation (PDPN) signal transduction (PDPN) extracellular space (VEGFA)

Anatomy Link Frequency body 2 PDPN (Homo sapiens) VEGFA (Homo sapiens)

Pain Link Frequency Relevance Heat anesthesia 1 5.00 Kinase C 1 5.00

Disease Link Frequency Relevance Heat Cancer 82 98.12 Metastasis 25 95.92 Skin Cancer 17 91.92 Malignant Neoplastic Disease 14 83.36 Breast Cancer 1 17.12 Small Cell Lung Carcinoma 2 5.00 Germ Cell And Embryonal Neoplasms 1 5.00 Respiratory Failure 1 5.00 Pressure And Volume Under Development 1 5.00 Adenocarcinoma 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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The body of our findings is that podoplanin in LSCCs can induce VEGF-C downregulation via the JNK signaling pathway(s), and can impair tumor-associated lymphangiogenesis and lymphogenous metastasis

podoplanin Positive_regulation (induce) of Negative_regulation (downregulation) of VEGF in body associated with cancer and metastasis

1) Confidence 0.09 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.81 Pain Relevance 0

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