INT344312

Context Info Confidence 0.05 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.26 Pain Relevance 0.04

signal transduction (PDPN, ITK) cell morphogenesis (PDPN) embryo development (PDPN) cytoplasm (ITK) cell proliferation (PDPN) cytosol (ITK)

PDPN (Homo sapiens) ITK (Homo sapiens)

Pain Link Frequency Relevance Heat Kinase C 1 70.44 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Cancer 82 72.12 Metastasis 25 64.64 Skin Cancer 17 51.12 Lung Cancer 1 33.20 Adenocarcinoma 1 32.04 Malignant Neoplastic Disease 14 25.48 Breast Cancer 1 14.96 Small Cell Lung Carcinoma 2 5.00 Germ Cell And Embryonal Neoplasms 1 5.00 Respiratory Failure 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As described above, podoplanin has the potential to induce EMT [29], so forced and long-term expression of podoplanin in our experimental conditions may cause several phenotypic changes of EBC-1 cells, resulting in the increased level of total JNK.

podoplanin Positive_regulation (induce) of EMT

1) Confidence 0.05 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.26 Pain Relevance 0.04

General Comments

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