INT344314

Context Info Confidence 0.35 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.67 Pain Relevance 0.13

nucleoplasm (MAPK8) mitochondrion (MAPK8) cell morphogenesis (PDPN) embryo development (PDPN) response to stress (MAPK8) cytoplasm (MAPK8)

PDPN (Homo sapiens) MAPK8 (Homo sapiens)

Pain Link Frequency Relevance Heat Kinase C 3 89.04 anesthesia 3 5.00

Disease Link Frequency Relevance Heat Cancer 246 90.72 Skin Cancer 51 69.72 Lung Cancer 3 51.80 Adenocarcinoma 3 50.64 Malignant Neoplastic Disease 42 44.08 Metastasis 75 37.76 Breast Cancer 3 33.56 Small Cell Lung Carcinoma 6 5.00 Germ Cell And Embryonal Neoplasms 3 5.00 Respiratory Failure 3 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A decreased level of phosphorylated JNK but not of total JNK was induced by siRNA-mediated podoplanin knockdown (Figures 6D and 7C), suggesting that podoplanin could induce JNK phosphorylation.

podoplanin Positive_regulation (induce) of Phosphorylation (phosphorylation) of JNK

1) Confidence 0.35 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.15 Pain Relevance 0.04

A decreased level of phosphorylated JNK but not of total JNK was induced by siRNA-mediated podoplanin knockdown (Figures 6D and 7C), suggesting that podoplanin could induce JNK phosphorylation.

podoplanin Positive_regulation (induce) of Phosphorylation (phosphorylation) of JNK

2) Confidence 0.35 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.26 Pain Relevance 0.04

A decreased level of phosphorylated JNK but not of total JNK was induced by siRNA-mediated podoplanin knockdown (Figures 6D and 7C), suggesting that podoplanin could induce JNK phosphorylation.

podoplanin Positive_regulation (induce) of Phosphorylation (phosphorylated) of JNK

3) Confidence 0.35 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.26 Pain Relevance 0.04

General Comments

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