INT344317

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.67
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (PDPN) embryo development (PDPN) cytoplasm (VEGFA)
cell proliferation (PDPN) signal transduction (PDPN) extracellular space (VEGFA)
PDPN (Homo sapiens)
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 2 60.64 Quite High
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 164 99.30 Very High Very High Very High
Metastasis 50 84.32 Quite High
Skin Cancer 34 41.32 Quite Low
Lung Cancer 2 23.40 Low Low
Adenocarcinoma 2 22.24 Low Low
Malignant Neoplastic Disease 28 15.68 Low Low
Breast Cancer 2 5.16 Low Low
Small Cell Lung Carcinoma 4 5.00 Very Low Very Low Very Low
Germ Cell And Embryonal Neoplasms 2 5.00 Very Low Very Low Very Low
Respiratory Failure 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, podoplanin-dependent downregulation of VEGF-C is mediated by the direct and/or indirect increase of active JNK level in LSCCs.
podoplanin Negative_regulation (downregulation) of VEGF
1) Confidence 0.08 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.24 Pain Relevance 0.03
These findings may be insufficient to determine the significance of VEGF-C for inducing tumor lymphangiogenesis in our animal model; however, VEGF-C expression in EBC-1 cells is thought to be a key factor to induce tumor-associated lymphangiogenesis, and podoplanin-mediated downregulation of the VEGF-C gene might be a possible mechanism underlying the different levels of lymphangiogenic activity between EBC1-Vs and EBC1-Ps.


podoplanin Negative_regulation (downregulation) of VEGF associated with cancer
2) Confidence 0.08 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.43 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox