INT344318

Context Info Confidence 0.11 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.92 Pain Relevance 0

cell morphogenesis (PDPN, RHOA) plasma membrane (PDPN, RHOA) cell cycle (PDPN, RHOA) cell differentiation (RHOA) mitochondrion (RHOA) intracellular (RHOA)

Anatomy Link Frequency MDCK 2 PDPN (Homo sapiens) RHOA (Homo sapiens)

Pain Link Frequency Relevance Heat anesthesia 1 5.00 Kinase C 1 5.00

Disease Link Frequency Relevance Heat Breast Cancer 1 94.96 Cancer 82 85.24 Malignant Neoplastic Disease 14 73.76 Metastasis 25 69.56 Adenocarcinoma 1 55.68 Skin Cancer 17 54.92 Lung Cancer 1 53.04 Small Cell Lung Carcinoma 2 5.00 Germ Cell And Embryonal Neoplasms 1 5.00 Respiratory Failure 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

For example, although podoplanin can induce RhoA activation and an epithelial-mesenchymal transition (EMT) in MDCK cells [29], it attenuated RhoA activity and could not induce EMT in a breast carcinoma cell line [27], suggesting that podoplanin exerts cell type-specific functions.

podoplanin Positive_regulation (induce) of Positive_regulation (activation) of RhoA in MDCK associated with breast cancer

1) Confidence 0.11 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.92 Pain Relevance 0

General Comments

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