INT344319

Context Info Confidence 0.35 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.50 Pain Relevance 0

nucleoplasm (MAPK8) mitochondrion (MAPK8) cell morphogenesis (PDPN) embryo development (PDPN) response to stress (MAPK8) cytoplasm (MAPK8)

MAPK8 (Homo sapiens) PDPN (Homo sapiens)

Pain Link Frequency Relevance Heat anesthesia 1 5.00 Kinase C 1 5.00

Disease Link Frequency Relevance Heat Skin Cancer 17 93.20 Cancer 82 80.96 Metastasis 25 64.48 Malignant Neoplastic Disease 14 56.00 Small Cell Lung Carcinoma 2 5.00 Germ Cell And Embryonal Neoplasms 1 5.00 Respiratory Failure 1 5.00 Pressure And Volume Under Development 1 5.00 Adenocarcinoma 1 5.00 Death 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Taken together, these findings suggest that JNK is a key pathway for inducing podoplanin-mediated downregulation of the VEGF-C gene in LSCCs.

JNK Positive_regulation (inducing) of podoplanin

1) Confidence 0.35 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.50 Pain Relevance 0

General Comments

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