INT344366

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Context Info
Confidence 0.53
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 5.02
Pain Relevance 3.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Efnb1) nucleus (Efnb1) cytoplasm (Efnb1)
Efnb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 308 97.44 Very High Very High Very High
B1 receptor 36 96.68 Very High Very High Very High
Inflammation 40 91.92 High High
Spinal cord 32 91.56 High High
antagonist 20 91.16 High High
cytokine 8 90.88 High High
Analgesic 92 89.76 High High
Opioid 52 89.20 High High
bradykinin 4 77.92 Quite High
Spontaneous pain 8 72.08 Quite High
Disease Link Frequency Relevance Heat
Cancer 304 99.30 Very High Very High Very High
Pain 320 97.44 Very High Very High Very High
INFLAMMATION 48 91.92 High High
Pancreatic Cancer 68 85.36 High High
Skin Cancer 32 81.24 Quite High
Neuropathic Pain 36 70.40 Quite High
Nociception 8 47.60 Quite Low
Hyperalgesia 12 5.00 Very Low Very Low Very Low
Bone Cancer 8 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
protein in cancer-inoculated regions, and significantly suppressed the gene expression of ephrin B1 in DRGs to a similar degree as Z-360.
Negative_regulation (suppressed) of Gene_expression (expression) of ephrin B1 associated with cancer
1) Confidence 0.53 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.47 Pain Relevance 1.06
The repeated administration of devazepide significantly suppressed the expression of the ephrin B1 gene compared with the vehicle-treated group in cancer-induced pain mice (p < 0.01) (Figure 6A); however, the gene expression of the Eph B1 receptor was unchanged in all of the test groups (Figure 6B).
Negative_regulation (suppressed) of Gene_expression (expression) of ephrin B1 associated with pain, cancer and b1 receptor
2) Confidence 0.53 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 0.91 Pain Relevance 0.49
production in cancer-inoculated regions, which in turn inhibits ephrin B1 gene expression, and tyrosine phosphorylation of NR2B.
Negative_regulation (inhibits) of Gene_expression (expression) of ephrin B1 associated with cancer
3) Confidence 0.53 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.64 Pain Relevance 1.12
Repeated administration of Z-360 suppressed the gene expression of ephrin B1 by 70.7% compared with the vehicle-treated group in cancer-induced pain mice (p < 0.001) (Figure 2A).
Negative_regulation (suppressed) of Gene_expression (expression) of ephrin B1 associated with pain and cancer
4) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.01 Pain Relevance 0.62

General Comments

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