INT344368

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Context Info
Confidence 0.63
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 18.39
Pain Relevance 13.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Efnb1) nucleus (Efnb1) cytoplasm (Efnb1)
Anatomy Link Frequency
spinal cord 10
paw 2
Efnb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 125 100.00 Very High Very High Very High
Pain 943 99.96 Very High Very High Very High
antagonist 60 99.28 Very High Very High Very High
Eae 16 98.64 Very High Very High Very High
Sciatic nerve 19 98.52 Very High Very High Very High
B1 receptor 108 98.32 Very High Very High Very High
allodynia 45 97.72 Very High Very High Very High
nMDA receptor 44 97.52 Very High Very High Very High
dorsal rhizotomy 1 97.36 Very High Very High Very High
Inflammation 129 97.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 912 100.00 Very High Very High Very High
Pain 982 99.96 Very High Very High Very High
Pancreatic Cancer 204 99.72 Very High Very High Very High
Injury 5 97.80 Very High Very High Very High
Neuropathic Pain 140 97.72 Very High Very High Very High
INFLAMMATION 154 97.04 Very High Very High Very High
Skin Cancer 96 88.56 High High
Nociception 30 85.04 High High
Bone Cancer 24 67.00 Quite High
Adhesions 1 64.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
production from cancer-inoculated regions induces the gene expression of ephrin B1 in DRGs, which then ephrin B1 enhances the tyrosine phosphorylation of NR2B via Eph B receptor in the spinal cord, finally leading to pain.
Positive_regulation (induces) of Gene_expression (expression) of ephrin B1 in spinal cord associated with pain, cancer and spinal cord
1) Confidence 0.63 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.42 Pain Relevance 0.87
induced the gene expression of ephrin B1 in L4-5 DRGs, we injected IL-1?
Positive_regulation (induced) of Gene_expression (expression) of ephrin B1
2) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.16 Pain Relevance 0.48
Ephrin B1 gene expression in DRGs was induced in a cancer-induced pain model in mice
Positive_regulation (induced) of Gene_expression (expression) of Ephrin B1 associated with pain and cancer
3) Confidence 0.42 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.69 Pain Relevance 1.25
injection (1000 pg/paw) into the plantar region of the right hind paw significantly induced the gene expression of ephrin B1 in L4-5 DRGs (p < 0.05), but not the Eph B1 receptor (Figure 5A, B).
Positive_regulation (induced) of Gene_expression (expression) of ephrin B1 in paw associated with b1 receptor
4) Confidence 0.42 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 0.96 Pain Relevance 0.49
Moreover, we observed that the CCK1 receptor antagonist devazepide similarly suppressed up-regulation of ephrin B1 gene expression and IL-1?
Positive_regulation (regulation) of Gene_expression (expression) of ephrin B1 associated with antagonist
5) Confidence 0.42 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2987997 Disease Relevance 1.32 Pain Relevance 1.03
from a cancer-inoculated region, induction of ephrin B1 gene expression in DRGs, and subsequent enhancement of tyrosine phosphorylation of NR2B in the spinal cord.
Positive_regulation (induction) of Gene_expression (expression) of ephrin B1 in spinal cord associated with cancer and spinal cord
6) Confidence 0.42 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.62 Pain Relevance 1.32
Z-360, a novel therapeutic agent for pancreatic cancer, prevents up-regulation of ephrin B1 gene expression and phosphorylation of NR2B via suppression of interleukin-1 ?
Positive_regulation (regulation) of Gene_expression (expression) of ephrin B1 associated with pancreatic cancer
7) Confidence 0.42 Published 2010 Journal Mol Pain Section Title Doc Link PMC2987997 Disease Relevance 0.94 Pain Relevance 0.75
In a mouse model of cancer-induced pain, ephrin B1 gene expression in dorsal root ganglia (DRGs) and the phosphorylation of NR2B in the spinal cord were induced.
Positive_regulation (induced) of Gene_expression (expression) of ephrin B1 in spinal cord associated with pain, cancer and spinal cord
8) Confidence 0.42 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2987997 Disease Relevance 1.18 Pain Relevance 0.96
increased in cancer-inoculated regions and induced the expression of the ephrin B1 gene in the periphery of DRGs.
Positive_regulation (increased) of Gene_expression (expression) of ephrin B1 associated with cancer
9) Confidence 0.42 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 2.25 Pain Relevance 1.56
increased in cancer-inoculated regions and induced the expression of the ephrin B1 gene in the periphery of DRGs.
Positive_regulation (induced) of Gene_expression (expression) of ephrin B1 associated with cancer
10) Confidence 0.42 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 2.22 Pain Relevance 1.53
To investigate the effects of increased gene expression of ephrin B1 in the mouse model of cancer-induced pain, we examined the change in the inflammatory mediator IL-1?
Positive_regulation (increased) of Gene_expression (expression) of ephrin B1 associated with pain, inflammation and cancer
11) Confidence 0.42 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.52 Pain Relevance 0.71
production in cancer-inoculated regions induces ephrin B1 gene expression in DRGs and then ephrin B1 enhances the tyrosine phosphorylation of NR2B via Eph B receptor in the spinal cord.
Positive_regulation (induces) of Gene_expression (expression) of ephrin B1 in spinal cord associated with cancer and spinal cord
12) Confidence 0.42 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2987997 Disease Relevance 1.37 Pain Relevance 1.14
Song et al. showed that expression of both ephrin-B1 and EphB1 are increased in the DRG and spinal cord after chronic constriction injury and dorsal rhizotomy or a combination of both [11].
Positive_regulation (increased) of Gene_expression (expression) of ephrin-B1 in spinal cord associated with dorsal rhizotomy, eae, injury and spinal cord
13) Confidence 0.22 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.73 Pain Relevance 1.22

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