INT344371

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Context Info
Confidence 0.57
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 3.35
Pain Relevance 2.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Efnb1) nucleus (Efnb1) cytoplasm (Efnb1)
Anatomy Link Frequency
spinal cord 1
Efnb1 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 9 100.00 Very High Very High Very High
Pain 231 99.96 Very High Very High Very High
Opioid 39 99.50 Very High Very High Very High
Spinal cord 24 99.36 Very High Very High Very High
Analgesic 69 97.58 Very High Very High Very High
antagonist 15 85.04 High High
Cholecystokinin 9 74.28 Quite High
Inflammation 30 5.00 Very Low Very Low Very Low
B1 receptor 27 5.00 Very Low Very Low Very Low
Neuropathic pain 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 240 99.96 Very High Very High Very High
Cancer 228 99.70 Very High Very High Very High
Pancreatic Cancer 51 90.40 High High
INFLAMMATION 36 5.00 Very Low Very Low Very Low
Neuropathic Pain 27 5.00 Very Low Very Low Very Low
Skin Cancer 24 5.00 Very Low Very Low Very Low
Hyperalgesia 9 5.00 Very Low Very Low Very Low
Bone Cancer 6 5.00 Very Low Very Low Very Low
Nociception 6 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a mouse model of cancer-induced pain, ephrin B1 gene expression in dorsal root ganglia (DRGs) and the phosphorylation of NR2B in the spinal cord were induced.
Phosphorylation (phosphorylation) of ephrin B1 in spinal cord associated with pain, cancer and spinal cord
1) Confidence 0.57 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2987997 Disease Relevance 1.17 Pain Relevance 0.95
Here, we investigated the mechanism of analgesic action of Z-360 in a severe cancer-induced pain model in mice, which is considered to be opioid-resistant, by examining ephrin B1 gene expression, N-methyl-D-aspartate receptor NR2B subunit phosphorylation, and interleukin-1?
Phosphorylation (phosphorylation) of ephrin B1 associated with pain, cancer, nmda receptor, analgesic and opioid
2) Confidence 0.57 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2987997 Disease Relevance 1.02 Pain Relevance 0.94
Z-360 treatment inhibited both ephrin B1 gene expression and the phosphorylation of NR2B.
Phosphorylation (phosphorylation) of ephrin B1
3) Confidence 0.57 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2987997 Disease Relevance 1.16 Pain Relevance 0.92

General Comments

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