INT344388

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.45
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Efnb1) transport (Grin2b) plasma membrane (Grin2b)
nucleus (Efnb1) embryo development (Grin2b) cytoplasm (Efnb1)
Anatomy Link Frequency
spinal cord 2
Efnb1 (Mus musculus)
Grin2b (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 8 98.92 Very High Very High Very High
Pain 77 97.64 Very High Very High Very High
Analgesic 23 92.64 High High
Opioid 13 66.56 Quite High
bradykinin 1 55.28 Quite High
Cholecystokinin 3 52.80 Quite High
Spontaneous pain 2 49.44 Quite Low
allodynia 3 47.76 Quite Low
B1 receptor 9 31.68 Quite Low
nMDA receptor 3 6.80 Low Low
Disease Link Frequency Relevance Heat
Cancer 76 98.38 Very High Very High Very High
Pain 80 97.64 Very High Very High Very High
Pancreatic Cancer 17 62.72 Quite High
Skin Cancer 8 51.60 Quite High
Neuropathic Pain 9 47.76 Quite Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Hyperalgesia 3 5.00 Very Low Very Low Very Low
Bone Cancer 2 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
production from cancer-inoculated regions induces the gene expression of ephrin B1 in DRGs, which then ephrin B1 enhances the tyrosine phosphorylation of NR2B via Eph B receptor in the spinal cord, finally leading to pain.
ephrin B1 Positive_regulation (enhances) of Phosphorylation (phosphorylation) of NR2B in spinal cord associated with pain, cancer and spinal cord
1) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.45 Pain Relevance 0.92

General Comments

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